251538-99-5

Basic information

• Product Name: 5-(4-chlorobenzylidene)-6,7-dihydrobenz[b]thiophen-4-one
• Synonyms: 5-(4-chlorobenzylidene)-6,7-dihydrobenz[b]thiophen-4-one
• CAS NO: 251538-99-5
• Molecular Weight: 274.771
• Mol File: 251538-99-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-chlorobenzylidene)-6,7-dihydrobenz[b]thiophen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorobenzylidene)-6,7-dihydrobenz[b]thiophen-4-one(251538-99-5)
• EPA Substance Registry System: 5-(4-chlorobenzylidene)-6,7-dihydrobenz[b]thiophen-4-one(251538-99-5)

Safety Data

• Hazardous Substances Data: 251538-99-5(Hazardous Substances Data)

Upstream product

• 13414-95-4 4-keto-4,5,6,7-tetrahydrothianaphthene 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 251539-00-1 3-cyano-4-(4-chlorophenyl)-5,6-dihydrothieno[2,3-h]quinolin-2(1H)-thione 
• 251539-11-4 7-amino-6-(4-chloro-phenyl)-4,5-dihydro-3,9-dithia-10-aza-dicyclopenta[a,g]naphthalene-8-carboxylic acid (4-chloro-phenyl)-amide 
• 251539-05-6 N-(4-chloro-phenyl)-2-[4-(4-chloro-phenyl)-3-cyano-5,6-dihydro-thieno[2,3-h]quinolin-2-ylsulfanyl]-acetamide 
• 251539-21-6 14-(4-chlorophenyl)-12,13-dihydro-[1,2,4]triazolo[4'',3'':1',6']pyrimido[4',5':4,5]thieno[2,3-b]thieno[2,3-h]quinolin-4(5H)-thione 
• 251539-08-9 [7-amino-6-(4-chloro-phenyl)-4,5-dihydro-3,9-dithia-10-aza-dicyclopenta[a,g]naphthalen-8-yl]-phenyl-methanone 
• 251539-18-1 12-(4-chlorophenyl)-4-hydrazino-10,11-dihydropyrimido[4',5':4,5]thieno[2,3-b]thieno[2,3-h]quinoline 
• 251539-25-0 3-amino-12-(4-chlorophenyl)-4-imino-10,11-dihydropyrimido[4',5':4,5]thieno[2,3-b]thieno[2,3-h]quinoline 
• 251539-14-7 12-(4-chlorophenyl)-10,11-dihydro-2-methyloxazino[4',5':4,5]thieno[2,3-b]thieno[2,3-h]quinolin-4-one 
• 251539-02-3 4-(4-chloro-phenyl)-2-(2-oxo-2-phenyl-ethylsulfanyl)-5,6-dihydro-thieno[2,3-h]quinoline-3-carbonitrile 
• 251539-09-0 7-amino-6-(4-chloro-phenyl)-4,5-dihydro-3,9-dithia-10-aza-dicyclopenta[a,g]naphthalene-8-carboxylic acid ethyl ester 
• 251539-03-4 [4-(4-chloro-phenyl)-3-cyano-5,6-dihydro-thieno[2,3-h]quinolin-2-ylsulfanyl]-acetic acid ethyl ester 
• 251539-10-3 7-amino-6-(4-chloro-phenyl)-4,5-dihydro-3,9-dithia-10-aza-dicyclopenta[a,g]naphthalene-8-carboxylic acid amide 
• 251539-24-9 4-(4-chlorophenyl)-2-cyano-3-ethoxymethyleneamino-5,6-dihydrothieno[2,3-b]thieno[2,3-h]quinoline 
• 251539-16-9 12-(4-chlorophenyl)-10,11-dihydropyrimido[4',5':4,5]thieno[2,3-b]thieno[2,3-h]quinolin-4(3H)-one 

Relevant articles and documents

A convenient synthesis of dithieno[2,3-b] [2,3-h]quinolines and pyrimido [4′,5′:4,5]thieno [2,3-b]thieno[2,3-h]quinolines

6,7-Dihydrobenz[b]thiophen-4(5H)one (1) was condensed with 4- chlorobenzaldehyde to yield the benzylidene derivative 2 which underwent Michael addition reacting with cyanothioacetamide in methanolic sodium methoxide solution to give the thienoquinoline 3. Compound 3 was reacted with α- halo compounds to obtain the substituted thio intermediates 4a-f, which upon treatment with sodium ethoxide produce the dithienoquinoline derivatives 5a-f. Thienopyrimidothienoquinoline e.g. 9 was obtained from the reaction of ?- aminocarboxamide derivative 5d with triethyl orthoformate.