(2E)-3-phenylprop-2-en-1-yl trifluoromethyl ether

Base Information

• Chemical Name: (2E)-3-phenylprop-2-en-1-yl trifluoromethyl ether
• CAS No.: 1241960-07-5
• Molecular Formula: C₁₀H₉F₃O
• Molecular Weight: 202.176
• Mol file: 1241960-07-5.mol

Synonyms:(2E)-3-phenylprop-2-en-1-yl trifluoromethyl ether

Chemical Property of (2E)-3-phenylprop-2-en-1-yl trifluoromethyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E)-3-phenylprop-2-en-1-yl trifluoromethyl ether

There total 8 articles about (2E)-3-phenylprop-2-en-1-yl trifluoromethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

trifluoromethyl 4-methylbenzenesulfonate (175676-42-3) + (2E)-3-phenyl-2-propen-1-ol (4407-36-7) → (2E)-3-phenylprop-2-en-1-yl trifluoromethyl ether (1241960-07-5)

Guidance literature:

With tetramethylammonium bromide; cesium fluoride; In N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl acetamide; at 40 ℃; for 26h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201711050

Reference yield: 70.0%

C13H13N4O4(1+)*CF3O(1-) + Cinnamyl bromide (4392-24-9) → (2E)-3-phenylprop-2-en-1-yl trifluoromethyl ether (1241960-07-5)

Guidance literature:

at 40 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1002/chem.202102809

Reference yield: 50.0%

(trifluoromethyl)trimethylsilane (81290-20-2) + (2E)-3-phenyl-2-propen-1-ol (4407-36-7) → (2E)-3-phenylprop-2-en-1-yl trifluoromethyl ether (1241960-07-5)

Guidance literature:

With potassium fluoride; 2-fluoropyridine; silver trifluoromethanesulfonate; Selectfluor; In ethyl acetate; at 20 ℃; for 12h; Glovebox; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02522

upstream raw materials:

trifluoromethyl trifluoromethanesulfonate

Cinnamyl bromide

2,4-dinitro-1-(trifluoromethoxy)benzene

3-bromo-1-phenyl-1-propenyl bromide