8,10-dibenzyl-8,10-diaza-1-<1'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene>-5-<((tert-butyldimethylsilyl)oxy)methyl>-6-hydroxy-2-oxabicyclo<4.2.2>decane-7,9-dione

Base Information

Chemical Name:8,10-dibenzyl-8,10-diaza-1-<1'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene>-5-<((tert-butyldimethylsilyl)oxy)methyl>-6-hydroxy-2-oxabicyclo<4.2.2>decane-7,9-dione
CAS No.:92125-40-1
Molecular Formula:C₄₁H₆₄N₂O₈Si₂
Molecular Weight:769.139
Hs Code.:

8,10-dibenzyl-8,10-diaza-1-<1'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene>-5-<((tert-butyldimethylsilyl)oxy)methyl>-6-hydroxy-2-oxabicyclo<4.2.2>decane-7,9-dione

Synonyms:8,10-dibenzyl-8,10-diaza-1-<1'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene>-5-<((tert-butyldimethylsilyl)oxy)methyl>-6-hydroxy-2-oxabicyclo<4.2.2>decane-7,9-dione

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Chemical Property of 8,10-dibenzyl-8,10-diaza-1-<1'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene>-5-<((tert-butyldimethylsilyl)oxy)methyl>-6-hydroxy-2-oxabicyclo<4.2.2>decane-7,9-dione

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Technology Process of 8,10-dibenzyl-8,10-diaza-1-<1'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene>-5-<((tert-butyldimethylsilyl)oxy)methyl>-6-hydroxy-2-oxabicyclo<4.2.2>decane-7,9-dione

There total 20 articles about 8,10-dibenzyl-8,10-diaza-1-<1'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene>-5-<((tert-butyldimethylsilyl)oxy)methyl>-6-hydroxy-2-oxabicyclo<4.2.2>decane-7,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95739-42-7
8,10-dibenzyl-8,10-diaza-1-<1'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene>-5-<((tert-butyldimethylsilyl)oxy)methyl>-2-oxabicyclo<4.2.2>decane-7,9-dione

: 92125-40-1
8,10-dibenzyl-8,10-diaza-1-<1'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene>-5-<((tert-butyldimethylsilyl)oxy)methyl>-6-hydroxy-2-oxabicyclo<4.2.2>decane-7,9-dione

Guidance literature:: With tert.-butyl lithium; oxygen; Yield given. Multistep reaction; 1.) THF, -100 deg C, 2 min; 2.) THF, -100 deg C, 10 min;
DOI:10.1021/ja00297a035

Reference yield:

: 81600-36-4
(+/-)-2,2,4-trimethyl-1,3-dioxolane-4-carboxaldehyde

: 92125-40-1
8,10-dibenzyl-8,10-diaza-1-<1'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene>-5-<((tert-butyldimethylsilyl)oxy)methyl>-6-hydroxy-2-oxabicyclo<4.2.2>decane-7,9-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, -100 deg C, 5 min; 2.) -100 deg C, 2 min

2: 99 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / Ambient temperature

3: 1.) tert-butyllithium; 2.) O₂ / 1.) THF, -100 deg C, 2 min; 2.) THF, -100 deg C, 10 min

With 2,6-dimethylpyridine; tert.-butyl lithium; oxygen; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/ja00297a035

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 92125-40-1
8,10-dibenzyl-8,10-diaza-1-<1'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylidene>-5-<((tert-butyldimethylsilyl)oxy)methyl>-6-hydroxy-2-oxabicyclo<4.2.2>decane-7,9-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 13.5 percent / (dimethylamino)pyridine, triethylamine / CH₂Cl₂ / 0.5 h / Ambient temperature

2: 91 percent / silver triflate / tetrahydrofuran / 0.33 h / Ambient temperature

3: 1.) LDA / 1.) THF, -100 deg C, 5 min; 2.) -100 deg C, 2 min

4: 99 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / Ambient temperature

5: 1.) tert-butyllithium; 2.) O₂ / 1.) THF, -100 deg C, 2 min; 2.) THF, -100 deg C, 10 min

With 2,6-dimethylpyridine; dmap; tert.-butyl lithium; oxygen; silver trifluoromethanesulfonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00297a035