(S)-(+)-2-HYDROXY-2-PHENYLPROPIONIC ACID

Base Information

• Chemical Name: (S)-(+)-2-HYDROXY-2-PHENYLPROPIONIC ACID
• CAS No.: 13113-71-8
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Hs Code.: 2918199090
• Mol file: 13113-71-8.mol

Synonyms:Benzeneaceticacid, a-hydroxy-a-methyl-, (S)-;Mandelic acid, a-methyl-, (S)-(+)- (8CI);(+)-2-Hydroxy-2-phenylpropionic acid;(+)-2-Phenyllactic acid;(+)-Atrolacticacid;(+)-a-Methylmandelic acid;(2S)-2-Hydroxy-2-phenylpropanoic acid;(2S)-2-Hydroxy-2-phenylpropionic acid;(S)-(+)-2-Hydroxy-2-phenylpropionic acid;(S)-(+)-Atrolactic acid;(S)-(+)-a-Methylmandelic acid;(S)-2-Hydroxy-2-phenylpropanoic acid;(S)-2-Phenyllactic acid;(S)-Atrolacticacid;(2S)-2-hydroxy-2-phenylpropanoic acid;Benzeneacetic acid, α-hydroxy-α-methyl-, (S)-;benzeneacetic acid, α-hydroxy-α-methyl-, (αS)-;

Chemical Property of (S)-(+)-2-HYDROXY-2-PHENYLPROPIONIC ACID

Chemical Property:

• Appearance/Colour: white fluffy fine crystalline powder
• Vapor Pressure: 8.3E-05mmHg at 25°C
• Melting Point: 112-115 °C
• Refractive Index: 1.568
• Boiling Point: 327.2 °C at 760 mmHg
• PKA: 3.53±0.25(Predicted)
• Flash Point: 165.9 °C
• PSA: 57.53000
• Density: 1.261 g/cm³
• LogP: 0.97870

Purity/Quality:

99% ^*data from raw suppliers

(S)-(+)-2-hydroxy-2-phenylpropionicacidAldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 24/25-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-(+)-2-HYDROXY-2-PHENYLPROPIONIC ACID

There total 53 articles about (S)-(+)-2-HYDROXY-2-PHENYLPROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

2-Hydroxy-2-phenyl-propionic acid [1,1']binaphthalenyl-2-yl ester → (S)-Atrolactic acid (13113-71-8) + (R)-[1,1'-binaphthalen]-2-ol (35216-79-6)

Guidance literature:

With potassium hydroxide; In ethanol; for 2h; Ambient temperature;

Reference yield: 93.0%

(S)-2-Hydroxy-2-phenyl-propionic acid 2'-hydroxy-[1,1']binaphthalenyl-2-yl ester → (S)-Atrolactic acid (13113-71-8)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Heating;

DOI:10.1248/cpb.42.957

Reference yield: 80.0%

2-hydroxy-2-phenyl-propionaldehyde (4361-50-6) → (S)-Atrolactic acid (13113-71-8)

Guidance literature:

With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In aq. phosphate buffer; water; acetonitrile; at 20 ℃; for 7h;

DOI:10.1002/chem.201504362

upstream raw materials:

pyruvic acid menthyl ester

2-Oxo-propionic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

trans-(4S,5S)-2-benzoyl-4-(methoxymethyl)-5-phenyl-2-oxazoline

methylmagnesium bromide

Downstream raw materials:

(S)-ethyl 2-hydroxy-2-phenylpropanoate

(S)-(+)-2-Hydroxy-2-phenyl-3-pentanon

(S)-methyl atrolactate

(S)-2-hydroxy-2-phenylpropanamide