phenyl-2 hydroxy-2 propanoate de (-) menthyle

Base Information

• Chemical Name: phenyl-2 hydroxy-2 propanoate de (-) menthyle
• CAS No.: 57133-37-6
• Molecular Formula: C₁₉H₂₈O₃
• Molecular Weight: 304.43
• Mol file: 57133-37-6.mol

Synonyms:

Chemical Property of phenyl-2 hydroxy-2 propanoate de (-) menthyle

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of phenyl-2 hydroxy-2 propanoate de (-) menthyle

There total 2 articles about phenyl-2 hydroxy-2 propanoate de (-) menthyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-menthol (2216-51-5) + (S)-Atrolactic acid (13113-71-8) → 2-hydroxy-2-phenyl-propionic acid menthyl ester (57133-37-6,57133-40-1)

Guidance literature:

With sulfuric acid; at 100 ℃; <(+)-atrolactinic acid >-l-menthyl ester;

Reference yield:

methylmagnesium bromide (75-16-1) + (-)menthyl phenylglyoxalate (6367-60-8,20229-41-8,67314-75-4,67405-83-8,88080-31-3,139406-28-3,139406-29-4,139406-30-7) → phenyl-2 hydroxy-2 propanoate de (-) menthyle (57133-37-6,57133-40-1)

Guidance literature:

With zinc(II) chloride; In tetrahydrofuran; ethanol; at -78 - 20 ℃; for 3h; Product distribution;

DOI:10.1016/S0040-4020(01)89110-9

Reference yield: 78.0%

phenyl-2 hydroxy-2 propanoate de (-) menthyle (57133-37-6,57133-40-1) → (R)-Atrolactic acid (3966-30-1)

Guidance literature:

With potassium hydroxide; water; In methanol; for 4h; Heating;

DOI:10.1016/S0040-4020(01)89110-9

upstream raw materials:

(-)-menthol

(S)-Atrolactic acid

methylmagnesium bromide

(-)menthyl phenylglyoxalate

Downstream raw materials:

(R)-Atrolactic acid

Refernces