Technology Process of (2R,3R,4R,5S)-2-(hydroxymethyl)-1-(6-((2-propylcyclohexyl)oxy)hexyl)piperidine-3,4,5-triol
There total 5 articles about (2R,3R,4R,5S)-2-(hydroxymethyl)-1-(6-((2-propylcyclohexyl)oxy)hexyl)piperidine-3,4,5-triol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,5-dideoxy-1,5-imino-D-glucitol;
With
acetic acid;
at 20 ℃;
C15H28O2;
With
acetic acid;
In
ethanol;
at 20 ℃;
for 1h;
Inert atmosphere;
With
palladium 10% on activated carbon; hydrogen;
In
ethanol;
for 24h;
DOI:10.1021/jm300171v
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h
2.1: acetic acid; pyridinium chlorochromate / dichloromethane / 4 h / 20 °C / Inert atmosphere
3.1: acetic acid / 20 °C
3.2: 1 h / 20 °C / Inert atmosphere
3.3: 24 h
With
palladium 10% on activated carbon; hydrogen; acetic acid; pyridinium chlorochromate;
In
ethanol; dichloromethane;
DOI:10.1021/jm300171v
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 18-crown-6 ether; potassium hydroxide / tetrahydrofuran / 48 h / 0 - 20 °C
2.1: pyridine / 3 h / 0 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 20 °C
3.2: 1 h / 75 °C
4.1: palladium 10% on activated carbon; hydrogen / ethanol / 24 h
5.1: acetic acid; pyridinium chlorochromate / dichloromethane / 4 h / 20 °C / Inert atmosphere
6.1: acetic acid / 20 °C
6.2: 1 h / 20 °C / Inert atmosphere
6.3: 24 h
With
pyridine; 18-crown-6 ether; palladium 10% on activated carbon; hydrogen; sodium hydride; acetic acid; pyridinium chlorochromate; potassium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm300171v
