2-amino-3-cyano-8-methyl-4-(4-chlorophenyl)-5,6,7,8-t etrahydroquinoline

Base Information

• Chemical Name: 2-amino-3-cyano-8-methyl-4-(4-chlorophenyl)-5,6,7,8-t etrahydroquinoline
• CAS No.: 1442374-61-9
• Molecular Formula: C₁₇H₁₆ClN₃
• Molecular Weight: 297.787

Synonyms:2-amino-3-cyano-8-methyl-4-(4-chlorophenyl)-5,6,7,8-t etrahydroquinoline

Chemical Property of 2-amino-3-cyano-8-methyl-4-(4-chlorophenyl)-5,6,7,8-t etrahydroquinoline

Chemical Property:

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Technology Process of 2-amino-3-cyano-8-methyl-4-(4-chlorophenyl)-5,6,7,8-t etrahydroquinoline

There total 1 articles about 2-amino-3-cyano-8-methyl-4-(4-chlorophenyl)-5,6,7,8-t etrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-chlorobenzaldehyde (104-88-1) + 2-Methylcyclohexanone (583-60-8) + malononitrile (109-77-3) → 2-amino-3-cyano-8-methyl-4-(4-chlorophenyl)-5,6,7,8-t etrahydroquinoline (1442374-61-9)

Guidance literature:

With ammonium acetate; In ethanol; Reflux;

DOI:10.1016/j.ejmech.2013.02.006

Reference yield: 89.0%

2-amino-3-cyano-8-methyl-4-(4-chlorophenyl)-5,6,7,8-t etrahydroquinoline (1442374-61-9) + Benzoyl isothiocyanate (532-55-8) → 1-benzoyl-3-(3-cyano-8-methyl-4-(4-chlorophenyl)-5,6,7,8-tetrahydroquinolin-2-yl)thiourea (1442374-63-1)

Guidance literature:

With potassium carbonate; In acetone; for 3h; Reflux;

DOI:10.1016/j.ejmech.2013.02.006

Reference yield: 82.0%

2-amino-3-cyano-8-methyl-4-(4-chlorophenyl)-5,6,7,8-t etrahydroquinoline (1442374-61-9) + thiourea (17356-08-0) → 4-amino-9-methyl-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinoline-2-thione (1442374-71-1)

Guidance literature:

at 260 - 300 ℃; for 1h;

DOI:10.1016/j.ejmech.2013.02.006

upstream raw materials:

4-chlorobenzaldehyde

2-Methylcyclohexanone

malononitrile

Downstream raw materials:

2-ethylthio-4-amino-9-methyl-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinoline

2-(4-amino-9-methyl-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinolin-2-ylthio)-1-phenylethanone

1-benzoyl-3-(3-cyano-8-methyl-4-(4-chlorophenyl)-5,6,7,8-tetrahydroquinolin-2-yl)thiourea

4-imino-9-methyl-3-phenyl-5-(4-chlorophenyl)-3,4,6,7,8,9-hexahydro-1H-pyrimido[4,5-b]quinoline-2-thione

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