2-(4-amino-9-methyl-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinolin-2-ylthio)-1-phenylethanone

Base Information

• Chemical Name: 2-(4-amino-9-methyl-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinolin-2-ylthio)-1-phenylethanone
• CAS No.: 1442374-75-5
• Molecular Formula: C₂₆H₂₃ClN₄OS
• Molecular Weight: 475.014

Synonyms:2-(4-amino-9-methyl-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinolin-2-ylthio)-1-phenylethanone

Chemical Property of 2-(4-amino-9-methyl-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinolin-2-ylthio)-1-phenylethanone

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Technology Process of 2-(4-amino-9-methyl-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinolin-2-ylthio)-1-phenylethanone

There total 4 articles about 2-(4-amino-9-methyl-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinolin-2-ylthio)-1-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-amino-9-methyl-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinoline-2-thione (1442374-71-1) + α-bromoacetophenone (70-11-1) → 2-(4-amino-9-methyl-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinolin-2-ylthio)-1-phenylethanone (1442374-75-5)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃;

DOI:10.1016/j.ejmech.2013.02.006

Reference yield:

2-Methylcyclohexanone (583-60-8) → 2-(4-amino-9-methyl-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinolin-2-ylthio)-1-phenylethanone (1442374-75-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium acetate / ethanol / Reflux

2: 1 h / 260 - 300 °C

3: sodium hydroxide / ethanol / 20 °C

With ammonium acetate; sodium hydroxide; In ethanol;

DOI:10.1016/j.ejmech.2013.02.006

Reference yield:

4-chlorobenzaldehyde (104-88-1) → 2-(4-amino-9-methyl-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinolin-2-ylthio)-1-phenylethanone (1442374-75-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium acetate / ethanol / Reflux

2: 1 h / 260 - 300 °C

3: sodium hydroxide / ethanol / 20 °C

With ammonium acetate; sodium hydroxide; In ethanol;

DOI:10.1016/j.ejmech.2013.02.006

upstream raw materials:

4-amino-9-methyl-5-(4-chlorophenyl)-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b]quinoline-2-thione

α-bromoacetophenone

2-Methylcyclohexanone

2-amino-3-cyano-8-methyl-4-(4-chlorophenyl)-5,6,7,8-t etrahydroquinoline

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