1,1-dimethylethyl (R)-N-[2-hydroxy-1-(4-methoxyphenyl)-ethyl]carbamate

Base Information

• Chemical Name: 1,1-dimethylethyl (R)-N-[2-hydroxy-1-(4-methoxyphenyl)-ethyl]carbamate
• CAS No.: 159848-74-5
• Molecular Formula: C₁₄H₂₁NO₄
• Molecular Weight: 267.325
• Mol file: 159848-74-5.mol

Synonyms:1,1-dimethylethyl (R)-N-[2-hydroxy-1-(4-methoxyphenyl)-ethyl]carbamate

Chemical Property of 1,1-dimethylethyl (R)-N-[2-hydroxy-1-(4-methoxyphenyl)-ethyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,1-dimethylethyl (R)-N-[2-hydroxy-1-(4-methoxyphenyl)-ethyl]carbamate

There total 17 articles about 1,1-dimethylethyl (R)-N-[2-hydroxy-1-(4-methoxyphenyl)-ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(4-methoxyphenyl)acetate (193073-85-7) → 1,1-dimethylethyl (R)-N-[2-hydroxy-1-(4-methoxyphenyl)-ethyl]carbamate (159848-74-5)

Guidance literature:

With sodium tetrahydroborate; ethanol; lithium chloride; In tetrahydrofuran; at 0 - 20 ℃; for 4.5h;

Reference yield: 70.0%

[2-(dimethyl-phenyl-silanyl)-1-(4-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester (849178-82-1) → 1,1-dimethylethyl (R)-N-[2-hydroxy-1-(4-methoxyphenyl)-ethyl]carbamate (159848-74-5)

Guidance literature:

With peracetic acid; sodium acetate; potassium bromide; In acetic acid; at 25 ℃;

DOI:10.1055/s-2004-836070

Reference yield: 65.0%

4-Methoxystyrene (637-69-4,24936-44-5) + tert-butyl carbazate (4248-19-5) → 1,1-dimethylethyl (R)-N-[2-hydroxy-1-(4-methoxyphenyl)-ethyl]carbamate (159848-74-5) + [2-Hydroxy-2-(4-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester (126395-30-0)

Guidance literature:

With sodium hydroxide; potassium dioxotetrahydroxoosmate(VI); tert-butylhypochlorite; 1,4-bis(9-O-dihydroquinidine)phthalazine; In propan-1-ol; water; at 0 ℃; for 1h;

DOI:10.1016/S0040-4039(98)00665-0

upstream raw materials:

methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(4-methoxyphenyl)acetate

4-Methoxystyrene

tert-butyl carbazate

[2-(dimethyl-phenyl-silanyl)-1-(4-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Downstream raw materials:

(R)-2-tert-butoxycarbonylamino-1-methanesulfonyloxy-2-(4-methoxyphenyl)ethane

(R)-2-amino-2-(4-methoxyphenyl)-1-ethanol

(R)-(1-(4-methoxyphenyl)-2-oxoethyl) tert-butyl carbamate

(4R,5R)-cytoxazone