8-(4-bromophenyl)-7-(2-(4-chlorophenoxy)ethyl)-2-(methylamino)-1H-purin-6(7H)-one

Base Information

Chemical Name:8-(4-bromophenyl)-7-(2-(4-chlorophenoxy)ethyl)-2-(methylamino)-1H-purin-6(7H)-one
CAS No.:1373822-37-7
Molecular Formula:C₂₀H₁₇BrClN₅O₂
Molecular Weight:474.744
Hs Code.:

Synonyms:8-(4-bromophenyl)-7-(2-(4-chlorophenoxy)ethyl)-2-(methylamino)-1H-purin-6(7H)-one

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Chemical Property of 8-(4-bromophenyl)-7-(2-(4-chlorophenoxy)ethyl)-2-(methylamino)-1H-purin-6(7H)-one

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Technology Process of 8-(4-bromophenyl)-7-(2-(4-chlorophenoxy)ethyl)-2-(methylamino)-1H-purin-6(7H)-one

There total 4 articles about 8-(4-bromophenyl)-7-(2-(4-chlorophenoxy)ethyl)-2-(methylamino)-1H-purin-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.1%

: 1373822-36-6
N-(4-amino-2-(methylamino)-6-oxo-1,6-dihydropyrimidin-5-yl)-4-bromo-N-(2-(4-chlorophenoxy)ethyl)benzamide

: 1373822-37-7
8-(4-bromophenyl)-7-(2-(4-chlorophenoxy)ethyl)-2-(methylamino)-1H-purin-6(7H)-one

Guidance literature:: With sodium t-butanolate; In isopropyl alcohol; at 100 ℃; Molecular sieve;
DOI:10.1021/jm300037x

Reference yield:

: 61693-25-2
5,6-diamino-2-(methylamino)pyrimidin-4(3H)-one

: 1373822-37-7
8-(4-bromophenyl)-7-(2-(4-chlorophenoxy)ethyl)-2-(methylamino)-1H-purin-6(7H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dichloromethane / Cooling with ice

2: borane-THF / tetrahydrofuran / 1.08 h / 23 °C / Reflux

3: base / 1,2-dichloro-ethane; N,N-dimethyl-formamide / 0.5 h

4: sodium t-butanolate / isopropyl alcohol / 100 °C / Molecular sieve

With borane-THF; potassium carbonate; sodium t-butanolate; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm300037x

Reference yield:

: 1373822-33-3
N-(4-amino-2-(methylamino)-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(4-chlorophenoxy)acetamide

: 1373822-37-7
8-(4-bromophenyl)-7-(2-(4-chlorophenoxy)ethyl)-2-(methylamino)-1H-purin-6(7H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / 1.08 h / 23 °C / Reflux

2: base / 1,2-dichloro-ethane; N,N-dimethyl-formamide / 0.5 h

3: sodium t-butanolate / isopropyl alcohol / 100 °C / Molecular sieve

With borane-THF; sodium t-butanolate; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm300037x