diethyl 4-(7-(2-(4-chlorophenoxy)ethyl)-6-hydroxy-2-(methylamino)-7H-purin-8-yl)phenylphosphonate

Base Information

Chemical Name:diethyl 4-(7-(2-(4-chlorophenoxy)ethyl)-6-hydroxy-2-(methylamino)-7H-purin-8-yl)phenylphosphonate
CAS No.:1373822-38-8
Molecular Formula:C₂₄H₂₇ClN₅O₅P
Molecular Weight:531.936
Hs Code.:

Synonyms:diethyl 4-(7-(2-(4-chlorophenoxy)ethyl)-6-hydroxy-2-(methylamino)-7H-purin-8-yl)phenylphosphonate

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Chemical Property of diethyl 4-(7-(2-(4-chlorophenoxy)ethyl)-6-hydroxy-2-(methylamino)-7H-purin-8-yl)phenylphosphonate

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Technology Process of diethyl 4-(7-(2-(4-chlorophenoxy)ethyl)-6-hydroxy-2-(methylamino)-7H-purin-8-yl)phenylphosphonate

There total 4 articles about diethyl 4-(7-(2-(4-chlorophenoxy)ethyl)-6-hydroxy-2-(methylamino)-7H-purin-8-yl)phenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1373822-37-7
8-(4-bromophenyl)-7-(2-(4-chlorophenoxy)ethyl)-2-(methylamino)-1H-purin-6(7H)-one

: 762-04-9
phosphonic acid diethyl ester

: 1373822-38-8
diethyl 4-(7-(2-(4-chlorophenoxy)ethyl)-6-hydroxy-2-(methylamino)-7H-purin-8-yl)phenylphosphonate

Guidance literature:: 8-(4-bromophenyl)-7-(2-(4-chlorophenoxy)ethyl)-2-(methylamino)-1H-purin-6(7H)-one; phosphonic acid diethyl ester; With dicyclohexylmethylamine; palladium diacetate; In ethanol; Sealed tube; Inert atmosphere;

With triphenylphosphine; In ethanol; at 100 ℃; Inert atmosphere;
DOI:10.1021/jm300037x

Reference yield:

: 61693-25-2
5,6-diamino-2-(methylamino)pyrimidin-4(3H)-one

: 1373822-38-8
diethyl 4-(7-(2-(4-chlorophenoxy)ethyl)-6-hydroxy-2-(methylamino)-7H-purin-8-yl)phenylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / dichloromethane / Cooling with ice

2.1: borane-THF / tetrahydrofuran / 1.08 h / 23 °C / Reflux

3.1: base / 1,2-dichloro-ethane; N,N-dimethyl-formamide / 0.5 h

4.1: sodium t-butanolate / isopropyl alcohol / 100 °C / Molecular sieve

5.1: dicyclohexylmethylamine; palladium diacetate / ethanol / Sealed tube; Inert atmosphere

5.2: 100 °C / Inert atmosphere

With borane-THF; dicyclohexylmethylamine; palladium diacetate; potassium carbonate; sodium t-butanolate; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm300037x

Reference yield:

: 1373822-33-3
N-(4-amino-2-(methylamino)-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(4-chlorophenoxy)acetamide

: 1373822-38-8
diethyl 4-(7-(2-(4-chlorophenoxy)ethyl)-6-hydroxy-2-(methylamino)-7H-purin-8-yl)phenylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 1.08 h / 23 °C / Reflux

2.1: base / 1,2-dichloro-ethane; N,N-dimethyl-formamide / 0.5 h

3.1: sodium t-butanolate / isopropyl alcohol / 100 °C / Molecular sieve

4.1: dicyclohexylmethylamine; palladium diacetate / ethanol / Sealed tube; Inert atmosphere

4.2: 100 °C / Inert atmosphere

With borane-THF; dicyclohexylmethylamine; palladium diacetate; sodium t-butanolate; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm300037x