(S)-4-{(S)-1-[(S)-1-[(1S,2S,4R)-2-Benzyloxy-4-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-1-isobutyl-pentylcarbamoyl]-2-(trityl-carbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-4-benzyloxycarbonylamino-butyric acid benzyl ester

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Chemical Name:(S)-4-{(S)-1-[(S)-1-[(1S,2S,4R)-2-Benzyloxy-4-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-1-isobutyl-pentylcarbamoyl]-2-(trityl-carbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-4-benzyloxycarbonylamino-butyric acid benzyl ester
CAS No.:864239-11-2
Molecular Formula:C₇₅H₈₆N₆O₁₂
Molecular Weight:1263.54
Hs Code.:

(S)-4-{(S)-1-[(S)-1-[(1S,2S,4R)-2-Benzyloxy-4-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-1-isobutyl-pentylcarbamoyl]-2-(trityl-carbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-4-benzyloxycarbonylamino-butyric acid benzyl ester

Synonyms:(S)-4-{(S)-1-[(S)-1-[(1S,2S,4R)-2-Benzyloxy-4-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-1-isobutyl-pentylcarbamoyl]-2-(trityl-carbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-4-benzyloxycarbonylamino-butyric acid benzyl ester

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Chemical Property of (S)-4-{(S)-1-[(S)-1-[(1S,2S,4R)-2-Benzyloxy-4-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-1-isobutyl-pentylcarbamoyl]-2-(trityl-carbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-4-benzyloxycarbonylamino-butyric acid benzyl ester

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Technology Process of (S)-4-{(S)-1-[(S)-1-[(1S,2S,4R)-2-Benzyloxy-4-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-1-isobutyl-pentylcarbamoyl]-2-(trityl-carbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-4-benzyloxycarbonylamino-butyric acid benzyl ester

There total 13 articles about (S)-4-{(S)-1-[(S)-1-[(1S,2S,4R)-2-Benzyloxy-4-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-1-isobutyl-pentylcarbamoyl]-2-(trityl-carbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-4-benzyloxycarbonylamino-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-{(2R,4S,5S)-5-[(S)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-(trityl-carbamoyl)-propionylamino]-4-benzyloxy-2,7-dimethyl-octanoylamino}-propionic acid benzyl ester

: 5680-86-4
N-benzyloxycarbonyl-5-O-benzyl-L-glutamic acid

: 864239-11-2
(S)-4-{(S)-1-[(S)-1-[(1S,2S,4R)-2-Benzyloxy-4-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-1-isobutyl-pentylcarbamoyl]-2-(trityl-carbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-4-benzyloxycarbonylamino-butyric acid benzyl ester

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 14h;
DOI:10.1021/jm050142+

Reference yield:

: ((1S,2S,4R)-2-Benzyloxy-1-isobutyl-4-methyl-5-oxo-pentyl)-carbamic acid tert-butyl ester

: 864239-11-2
(S)-4-{(S)-1-[(S)-1-[(1S,2S,4R)-2-Benzyloxy-4-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-1-isobutyl-pentylcarbamoyl]-2-(trityl-carbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-4-benzyloxycarbonylamino-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 38.3 mg / aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / acetonitrile; 2-methyl-propan-2-ol / 0.5 h / 0 °C

2: 77 percent / PyBOP; i-Pr₂NEt / CH₂Cl₂ / 14 h / 5 °C

3: HCl / dioxane / 0.33 h

4: 65 mg / PyBOP; i-Pr₂NEt / CH₂Cl₂ / 14 h / 0 - 20 °C

5: HCl / dioxane / 0.33 h

6: 56 mg / PyBOP; i-Pr₂NEt / CH₂Cl₂ / 14 h / 0 - 20 °C

7: HCl / dioxane / 0.33 h

8: 52 mg / PyBOP; i-Pr₂NEt / CH₂Cl₂ / 14 h / 0 - 20 °C

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm050142+

Reference yield:

: 864239-05-4
2,2-dimethylpropionic acid (5S)-tert-butoxycarbonylamino-(4S)-hydroxy-(2R),7-dimethyloctyl ester

: 864239-11-2
(S)-4-{(S)-1-[(S)-1-[(1S,2S,4R)-2-Benzyloxy-4-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-1-isobutyl-pentylcarbamoyl]-2-(trityl-carbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-4-benzyloxycarbonylamino-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 69 percent / n-Bu₄NI; NaH / tetrahydrofuran / 14 h / 20 °C

2: DibalH / CH₂Cl₂; toluene / 0.5 h / -78 °C

3: Et₃N; SO₃*Py / dimethylsulfoxide; CH₂Cl₂ / 1 h / 20 °C

4: 38.3 mg / aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / acetonitrile; 2-methyl-propan-2-ol / 0.5 h / 0 °C

5: 77 percent / PyBOP; i-Pr₂NEt / CH₂Cl₂ / 14 h / 5 °C

6: HCl / dioxane / 0.33 h

7: 65 mg / PyBOP; i-Pr₂NEt / CH₂Cl₂ / 14 h / 0 - 20 °C

8: HCl / dioxane / 0.33 h

9: 56 mg / PyBOP; i-Pr₂NEt / CH₂Cl₂ / 14 h / 0 - 20 °C

10: HCl / dioxane / 0.33 h

11: 52 mg / PyBOP; i-Pr₂NEt / CH₂Cl₂ / 14 h / 0 - 20 °C

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; pyridine-SO₃ complex; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm050142+