(4S)-benzyloxy-(5S)-tert-butoxycarbonylamino-(2R),7-dimethyloctanoic acid

Base Information

Chemical Name:(4S)-benzyloxy-(5S)-tert-butoxycarbonylamino-(2R),7-dimethyloctanoic acid
CAS No.:864239-07-6
Molecular Formula:C₂₂H₃₅NO₅
Molecular Weight:393.524
Hs Code.:

Synonyms:(4S)-benzyloxy-(5S)-tert-butoxycarbonylamino-(2R),7-dimethyloctanoic acid

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Chemical Property of (4S)-benzyloxy-(5S)-tert-butoxycarbonylamino-(2R),7-dimethyloctanoic acid

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Technology Process of (4S)-benzyloxy-(5S)-tert-butoxycarbonylamino-(2R),7-dimethyloctanoic acid

There total 6 articles about (4S)-benzyloxy-(5S)-tert-butoxycarbonylamino-(2R),7-dimethyloctanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ((1S,2S,4R)-2-Benzyloxy-1-isobutyl-4-methyl-5-oxo-pentyl)-carbamic acid tert-butyl ester

: 864239-07-6
(4S)-benzyloxy-(5S)-tert-butoxycarbonylamino-(2R),7-dimethyloctanoic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In acetonitrile; tert-butyl alcohol; at 0 ℃; for 0.5h;
DOI:10.1021/jm050142+

Reference yield:

: 864239-05-4
2,2-dimethylpropionic acid (5S)-tert-butoxycarbonylamino-(4S)-hydroxy-(2R),7-dimethyloctyl ester

: 864239-07-6
(4S)-benzyloxy-(5S)-tert-butoxycarbonylamino-(2R),7-dimethyloctanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 69 percent / n-Bu₄NI; NaH / tetrahydrofuran / 14 h / 20 °C

2: DibalH / CH₂Cl₂; toluene / 0.5 h / -78 °C

3: Et₃N; SO₃*Py / dimethylsulfoxide; CH₂Cl₂ / 1 h / 20 °C

4: 38.3 mg / aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / acetonitrile; 2-methyl-propan-2-ol / 0.5 h / 0 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; pyridine-SO₃ complex; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm050142+

Reference yield:

: ((1S,2S,4R)-2-Benzyloxy-5-hydroxy-1-isobutyl-4-methyl-pentyl)-carbamic acid tert-butyl ester

: 864239-07-6
(4S)-benzyloxy-(5S)-tert-butoxycarbonylamino-(2R),7-dimethyloctanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N; SO₃*Py / dimethylsulfoxide; CH₂Cl₂ / 1 h / 20 °C

2: 38.3 mg / aq. NaClO₂; NaH₂PO₄; 2-methyl-2-butene / acetonitrile; 2-methyl-propan-2-ol / 0.5 h / 0 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; pyridine-SO₃ complex; triethylamine; In dichloromethane; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm050142+