5-<3-(4-benzyloxybenzyloxy)benzyl>-1-<(2-(3-carboxypropionyloxy)ethoxy)methyl>uracil

Base Information

Chemical Name:5-<3-(4-benzyloxybenzyloxy)benzyl>-1-<(2-(3-carboxypropionyloxy)ethoxy)methyl>uracil
CAS No.:110522-25-3
Molecular Formula:C₃₂H₃₂N₂O₉
Molecular Weight:588.614
Hs Code.:

Synonyms:5-<3-(4-benzyloxybenzyloxy)benzyl>-1-<(2-(3-carboxypropionyloxy)ethoxy)methyl>uracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-<3-(4-benzyloxybenzyloxy)benzyl>-1-<(2-(3-carboxypropionyloxy)ethoxy)methyl>uracil

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Technology Process of 5-<3-(4-benzyloxybenzyloxy)benzyl>-1-<(2-(3-carboxypropionyloxy)ethoxy)methyl>uracil

There total 5 articles about 5-<3-(4-benzyloxybenzyloxy)benzyl>-1-<(2-(3-carboxypropionyloxy)ethoxy)methyl>uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 108-30-5
succinic acid anhydride

: 105847-66-3
5-<3-(4-benzyloxybenzyloxy)benzyl>-1-<(2-hydroxyethoxy)methyl>uracil

: 110522-25-3
5-<3-(4-benzyloxybenzyloxy)benzyl>-1-<(2-(3-carboxypropionyloxy)ethoxy)methyl>uracil

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 2h;
DOI:10.1002/jhet.5570230609

Reference yield:

: 110522-18-4
Benzoic acid 2-[5-(3-benzyloxy-benzyl)-4-methoxy-2-oxo-2H-pyrimidin-1-ylmethoxy]-ethyl ester

: 110522-25-3
5-<3-(4-benzyloxybenzyloxy)benzyl>-1-<(2-(3-carboxypropionyloxy)ethoxy)methyl>uracil

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / 6N aq. HCl, H₂ / Pd/C / methanol / 1 h / 2206.5 Torr

2: 70 percent / potassium carbonate / dimethylformamide / 40 °C / overnight

3: 85 percent / aq. NaOH / methanol / 4 h / Ambient temperature

4: 77 percent / aq. NaOH / methanol / 48 h / 60 °C

5: 91 percent / triethyl amine / dimethylformamide / 2 h / 60 °C

With hydrogenchloride; sodium hydroxide; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570230609

Reference yield:

: 110522-19-5
5-(3-hydroxybenzyl)-1-<(2-benzoyloxyethoxy)methyl>-2-keto-4-methoxypyrimidine

: 110522-25-3
5-<3-(4-benzyloxybenzyloxy)benzyl>-1-<(2-(3-carboxypropionyloxy)ethoxy)methyl>uracil

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / potassium carbonate / dimethylformamide / 40 °C / overnight

2: 85 percent / aq. NaOH / methanol / 4 h / Ambient temperature

3: 77 percent / aq. NaOH / methanol / 48 h / 60 °C

4: 91 percent / triethyl amine / dimethylformamide / 2 h / 60 °C

With sodium hydroxide; potassium carbonate; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570230609