(R)-1-(naphthalen-1-yl)ethanol

Base Information

• Chemical Name: (R)-1-(naphthalen-1-yl)ethanol
• CAS No.: 42177-25-3
• Molecular Formula: C12H12O
• Molecular Weight: 172.227
• Hs Code.: 29062990
• DSSTox Substance ID: DTXSID90426275
• Nikkaji Number: J53.196K
• Wikidata: Q72493749
• ChEMBL ID: CHEMBL378554
• Mol file: 42177-25-3.mol

Synonyms:(R)-1-(naphthalen-1-yl)ethanol;42177-25-3;(R)-(+)-1-(1-Naphthyl)ethanol;(1R)-1-naphthalen-1-ylethanol;(R)-1-(1-naphthyl)ethanol;(1R)-1-(Naphthalen-1-yl)ethan-1-ol;CHEMBL378554;(1R)-1-(1-naphthyl)ethanol;MFCD00077830;r-1-(1-naphthyl)ethanol;SCHEMBL1154786;R(+)-1-(1-naphthyl)ethanol;DTXSID90426275;CDRQOYRPWJULJN-SECBINFHSA-N;AMY14873;BDBM50183607;(+)-(R)-1-Naphthalen-1-ylethanol;AKOS012670048;AC-9387;CS-W017591;AS-60104;(R)-(+)-|A?Methyl-1-naphthalenemethanol;A6897;(R)-(+)- alpha -Methyl-1-naphthalenemethanol;EN300-1847830;(R)-(+)-alpha-Methyl-1-naphthalenemethanol, 99%

Chemical Property of (R)-1-(naphthalen-1-yl)ethanol

Chemical Property:

• Vapor Pressure: 0.000177mmHg at 25°C
• Melting Point: 47-49 °C(lit.)
• Refractive Index: 1.632
• Boiling Point: 316 °C at 760 mmHg
• PKA: 14.29±0.20(Predicted)
• Flash Point: 145.4 °C
• PSA: 20.23000
• Density: 1.113 g/cm³
• LogP: 2.89310
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 172.088815002
• Heavy Atom Count: 13
• Complexity: 167

Purity/Quality:

97% ^*data from raw suppliers

(R)-(+)-?-Methyl-1-naphthalenemethanol,99% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC2=CC=CC=C21)O
• Isomeric SMILES: C[C@H](C1=CC=CC2=CC=CC=C21)O
• Uses: (R)?-?1-?(Naphthalen-?1-?yl)?ethanol is a coupling reagent used in the synthesis of ferrocene aminophosphoxazoline ligands.

Technology Process of (R)-1-(naphthalen-1-yl)ethanol

There total 100 articles about (R)-1-(naphthalen-1-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Isopropenyl acetate (108-22-5) + 1-(1-naphthyl)ethanol (57605-95-5,1517-72-2) → (S)-1-(1-Naphthyl)ethanol (15914-84-8,1517-72-2) + (R)-1-(naphth-1-yl)ethanol (42177-25-3,1517-72-2) + 1-(naphthalen-1-yl)ethyl acetate (16197-95-8,57573-90-7,92697-21-7,16197-94-7)

Guidance literature:

With Candida antarctica lipase B; dicarbonyl(chloro)(η⁵-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate; In tetrahydrofuran; toluene; at 20 ℃; for 24h;

DOI:10.1021/ja051576x

Reference yield: 62.0%

1-(1-naphthyl)ethanol (57605-95-5,1517-72-2) → 1'-naphthacetophenone (941-98-0) + (S)-1-(1-Naphthyl)ethanol (15914-84-8,1517-72-2) + (R)-1-(naphth-1-yl)ethanol (42177-25-3,1517-72-2)

Guidance literature:

With (1R)-N-oxyl-1-(N-benzylcarbamoyl)-8-azabicyclo[3.2.1]octane; sodium hydrogencarbonate; sodium bromide; In dichloromethane; water; at 0 ℃; optical yield given as %ee; enantioselective reaction; Electrochemical reaction;

DOI:10.1016/j.tetasy.2008.12.011

Reference yield: 46.0%

vinyl acetate (108-05-4,9003-20-7) + 1-(1-naphthyl)ethanol (57605-95-5,1517-72-2) → (S)-1-(1-Naphthyl)ethanol (15914-84-8,1517-72-2) + (R)-1-(naphth-1-yl)ethanol (42177-25-3,1517-72-2) + 1-(naphthalen-1-yl)ethyl acetate (16197-95-8,57573-90-7,92697-21-7,16197-94-7)

Guidance literature:

With lipase LIP; In octane; at 30 ℃; for 0.15h; Yields of byproduct given;

DOI:10.1271/bbb.59.271

upstream raw materials:

1'-naphthacetophenone

1-ethylnapthelene

1-(1-naphthyl)ethanol

acetic acid 1-(1-naphthyl)ethyl ester

Downstream raw materials:

(R)-1-(naphthalen-1-yl)ethyl benzoate

1-(1-naphthyl)ethanol