4-(4-amino-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3,5-dichlorobenzonitrile

Base Information

Chemical Name:4-(4-amino-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3,5-dichlorobenzonitrile
CAS No.:1378039-85-0
Molecular Formula:C₁₃H₆Cl₂FN₅
Molecular Weight:322.129
Hs Code.:

Synonyms:4-(4-amino-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3,5-dichlorobenzonitrile

Suppliers and Price of 4-(4-amino-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3,5-dichlorobenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(4-amino-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3,5-dichlorobenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(4-amino-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3,5-dichlorobenzonitrile

There total 8 articles about 4-(4-amino-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3,5-dichlorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1378039-84-9
[2-(2,6-dichloro-4-cyanophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-yl]-carbamic acid tert-butyl ester

: 1378039-85-0
4-(4-amino-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3,5-dichlorobenzonitrile

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 18h;

Reference yield:

: 2546-56-7
4-chloro-3-fluoro-pyridine

: 1378039-85-0
4-(4-amino-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3,5-dichlorobenzonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 18.75 h / -78 - -30 °C

1.2: 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: triethylamine; titanium tetrachloride / dichloromethane / 1.16 h / 20 °C

4.1: toluene / 1 h / 20 °C / Reflux

5.1: dihydrogen peroxide; methyltrioxorhenium(VII) / dichloromethane / 3 h / 20 °C

6.1: phosphorus(V) oxybromide / 1,2-dichloro-ethane / 3.5 h / 0 - 20 °C

7.1: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 1.5 h / 60 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C

With hydrogenchloride; potassium phosphate; n-butyllithium; sodium azide; dihydrogen peroxide; titanium tetrachloride; methyltrioxorhenium(VII); triethylamine; diisopropylamine; phosphorus(V) oxybromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1060802-34-7
4-chloro-5-fluoropyridine-3-carboxaldehyde

: 1378039-85-0
4-(4-amino-7-fluoropyrazolo[4,3-c]pyridin-2-yl)-3,5-dichlorobenzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

2: triethylamine; titanium tetrachloride / dichloromethane / 1.16 h / 20 °C

3: toluene / 1 h / 20 °C / Reflux

4: dihydrogen peroxide; methyltrioxorhenium(VII) / dichloromethane / 3 h / 20 °C

5: phosphorus(V) oxybromide / 1,2-dichloro-ethane / 3.5 h / 0 - 20 °C

6: potassium phosphate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene; water / 1.5 h / 60 °C / Inert atmosphere

7: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C

With hydrogenchloride; potassium phosphate; sodium azide; dihydrogen peroxide; titanium tetrachloride; methyltrioxorhenium(VII); triethylamine; phosphorus(V) oxybromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;