2-(4-(diethoxyphosphoryl)phenyl)-2-phenylacetic acid

Base Information

Chemical Name:2-(4-(diethoxyphosphoryl)phenyl)-2-phenylacetic acid
CAS No.:1428526-76-4
Molecular Formula:C₁₈H₂₁O₅P
Molecular Weight:348.336
Hs Code.:

Synonyms:2-(4-(diethoxyphosphoryl)phenyl)-2-phenylacetic acid

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Chemical Property of 2-(4-(diethoxyphosphoryl)phenyl)-2-phenylacetic acid

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Technology Process of 2-(4-(diethoxyphosphoryl)phenyl)-2-phenylacetic acid

There total 6 articles about 2-(4-(diethoxyphosphoryl)phenyl)-2-phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1428526-75-3
diethyl 4-[(methoxycarbonyl)(phenyl)methyl]phenylphosphonate

: 1428526-76-4
2-(4-(diethoxyphosphoryl)phenyl)-2-phenylacetic acid

Guidance literature:: With lithium hydroxide monohydrate; In methanol; water;

Reference yield:

: 90-90-4
(4-bromophenyl)(phenyl)methanone

: 1428526-76-4
2-(4-(diethoxyphosphoryl)phenyl)-2-phenylacetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: trimethylsulfoxonium iodide; sodium hydride / tetrahydrofuran; mineral oil / 16 h / 55 °C / Inert atmosphere

2: boron trifluoride diethyl etherate / toluene / 0.67 h / -10 - 20 °C

3: Jones reagent / isopropyl alcohol; acetone / 0.5 h / -10 °C

4: sulfuric acid / 14 h / 60 °C

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / toluene / 110 °C

6: lithium hydroxide monohydrate / methanol; water

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; sulfuric acid; Jones reagent; boron trifluoride diethyl etherate; trimethylsulfoxonium iodide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; water; isopropyl alcohol; acetone; toluene; mineral oil;

Reference yield:

: 5359-48-8
methyl 2-(4-bromophenyl)-2-phenylacetate

: 1428526-76-4
2-(4-(diethoxyphosphoryl)phenyl)-2-phenylacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / toluene / 110 °C

2: lithium hydroxide monohydrate / methanol; water

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; triethylamine; In methanol; water; toluene;