diethyl 4-(2-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-ylamino)-2-oxo-1-phenylethyl)phenylphosphonate

Base Information

• Chemical Name: diethyl 4-(2-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-ylamino)-2-oxo-1-phenylethyl)phenylphosphonate
• CAS No.: 1428526-77-5
• Molecular Formula: C₂₅H₂₆N₅O₅P
• Molecular Weight: 507.486
• Mol file: 1428526-77-5.mol

Synonyms:diethyl 4-(2-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-ylamino)-2-oxo-1-phenylethyl)phenylphosphonate

Chemical Property of diethyl 4-(2-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-ylamino)-2-oxo-1-phenylethyl)phenylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 4-(2-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-ylamino)-2-oxo-1-phenylethyl)phenylphosphonate

There total 7 articles about diethyl 4-(2-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-ylamino)-2-oxo-1-phenylethyl)phenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

5-amino-2-(1H-pyrazol-1-yl)pyrimidin-4-ol (1343460-33-2) + 2-(4-(diethoxyphosphoryl)phenyl)-2-phenylacetic acid (1428526-76-4) → diethyl 4-(2-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-ylamino)-2-oxo-1-phenylethyl)phenylphosphonate (1428526-77-5)

Guidance literature:

With triethylamine; HATU; In acetonitrile; at 20 ℃;

Reference yield:

methyl 2-(4-bromophenyl)-2-phenylacetate (5359-48-8) → diethyl 4-(2-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-ylamino)-2-oxo-1-phenylethyl)phenylphosphonate (1428526-77-5)

Guidance literature:

Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / toluene / 110 °C

2: lithium hydroxide monohydrate / methanol; water

3: triethylamine; HATU / acetonitrile / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; triethylamine; HATU; In methanol; water; toluene; acetonitrile;

Reference yield:

(4-bromophenyl)(phenyl)methanone (90-90-4) → diethyl 4-(2-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-ylamino)-2-oxo-1-phenylethyl)phenylphosphonate (1428526-77-5)

Guidance literature:

Multi-step reaction with 7 steps

1: trimethylsulfoxonium iodide; sodium hydride / tetrahydrofuran; mineral oil / 16 h / 55 °C / Inert atmosphere

2: boron trifluoride diethyl etherate / toluene / 0.67 h / -10 - 20 °C

3: Jones reagent / isopropyl alcohol; acetone / 0.5 h / -10 °C

4: sulfuric acid / 14 h / 60 °C

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / toluene / 110 °C

6: lithium hydroxide monohydrate / methanol; water

7: triethylamine; HATU / acetonitrile / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; sulfuric acid; Jones reagent; boron trifluoride diethyl etherate; trimethylsulfoxonium iodide; sodium hydride; triethylamine; HATU; In tetrahydrofuran; methanol; water; isopropyl alcohol; acetone; toluene; acetonitrile; mineral oil;

upstream raw materials:

methyl 2-(4-bromophenyl)-2-phenylacetate

diethyl 4-[(methoxycarbonyl)(phenyl)methyl]phenylphosphonate

5-amino-2-(1H-pyrazol-1-yl)pyrimidin-4-ol

2-(4-(diethoxyphosphoryl)phenyl)-2-phenylacetic acid

Refernces

• 1、 -. "SUBSTITUTED PYRIMIDINES". . . Retrieved 2013/04/10.