(R)-2-[2-(4-Acetoxy-benzyloxycarbonylamino)-acetylamino]-3-{(R)-2-[2-(4-acetoxy-benzyloxycarbonylamino)-acetylamino]-2-allyloxycarbonyl-ethyldisulfanyl}-propionic acid allyl ester

Base Information

Chemical Name:(R)-2-[2-(4-Acetoxy-benzyloxycarbonylamino)-acetylamino]-3-{(R)-2-[2-(4-acetoxy-benzyloxycarbonylamino)-acetylamino]-2-allyloxycarbonyl-ethyldisulfanyl}-propionic acid allyl ester
CAS No.:201407-28-5
Molecular Formula:C₃₆H₄₂N₄O₁₄S₂
Molecular Weight:818.88
Hs Code.:

(R)-2-[2-(4-Acetoxy-benzyloxycarbonylamino)-acetylamino]-3-{(R)-2-[2-(4-acetoxy-benzyloxycarbonylamino)-acetylamino]-2-allyloxycarbonyl-ethyldisulfanyl}-propionic acid allyl ester

Synonyms:(R)-2-[2-(4-Acetoxy-benzyloxycarbonylamino)-acetylamino]-3-{(R)-2-[2-(4-acetoxy-benzyloxycarbonylamino)-acetylamino]-2-allyloxycarbonyl-ethyldisulfanyl}-propionic acid allyl ester

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Chemical Property of (R)-2-[2-(4-Acetoxy-benzyloxycarbonylamino)-acetylamino]-3-{(R)-2-[2-(4-acetoxy-benzyloxycarbonylamino)-acetylamino]-2-allyloxycarbonyl-ethyldisulfanyl}-propionic acid allyl ester

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Technology Process of (R)-2-[2-(4-Acetoxy-benzyloxycarbonylamino)-acetylamino]-3-{(R)-2-[2-(4-acetoxy-benzyloxycarbonylamino)-acetylamino]-2-allyloxycarbonyl-ethyldisulfanyl}-propionic acid allyl ester

There total 5 articles about (R)-2-[2-(4-Acetoxy-benzyloxycarbonylamino)-acetylamino]-3-{(R)-2-[2-(4-acetoxy-benzyloxycarbonylamino)-acetylamino]-2-allyloxycarbonyl-ethyldisulfanyl}-propionic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 50444-49-0
(4-Acetoxy-benzyloxycarbonylamino)-acetic acid

: L-cystine bis(allyl ester)

: 201407-28-5
(R)-2-[2-(4-Acetoxy-benzyloxycarbonylamino)-acetylamino]-3-{(R)-2-[2-(4-acetoxy-benzyloxycarbonylamino)-acetylamino]-2-allyloxycarbonyl-ethyldisulfanyl}-propionic acid allyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1002/anie.199722381

Reference yield: 74.0%

: 50444-49-0
(4-Acetoxy-benzyloxycarbonylamino)-acetic acid

: (R)-2-Amino-3-((R)-2-amino-2-carboxy-ethyldisulfanyl)-propionic acid; compound with toluene-4-sulfonic acid

: 201407-28-5
(R)-2-[2-(4-Acetoxy-benzyloxycarbonylamino)-acetylamino]-3-{(R)-2-[2-(4-acetoxy-benzyloxycarbonylamino)-acetylamino]-2-allyloxycarbonyl-ethyldisulfanyl}-propionic acid allyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; diisopropyl-carbodiimide; In tetrahydrofuran; for 24h; Ambient temperature;
DOI:10.1021/ja9805627

Reference yield:

: 623-05-2
(4-hydroxyphenyl)methanol

: 201407-28-5
(R)-2-[2-(4-Acetoxy-benzyloxycarbonylamino)-acetylamino]-3-{(R)-2-[2-(4-acetoxy-benzyloxycarbonylamino)-acetylamino]-2-allyloxycarbonyl-ethyldisulfanyl}-propionic acid allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / Et₃N / ethyl acetate / 5 h

2: 98 percent / toluene / Ambient temperature

3: Et₃N / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, 12 h

4: 74 percent / Et₃N, HOBt, diisopropylcarbodiimide / tetrahydrofuran / 24 h / Ambient temperature

With benzotriazol-1-ol; triethylamine; diisopropyl-carbodiimide; In tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1021/ja9805627