N'-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-N'-(4-fluoro-benzyl)-hydrazinecarboxylic acid tert-butyl ester

Base Information

Chemical Name:N'-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-N'-(4-fluoro-benzyl)-hydrazinecarboxylic acid tert-butyl ester
CAS No.:149267-85-6
Molecular Formula:C₂₇H₃₈FN₃O₅
Molecular Weight:503.614
Hs Code.:

Synonyms:N'-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-N'-(4-fluoro-benzyl)-hydrazinecarboxylic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N'-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-N'-(4-fluoro-benzyl)-hydrazinecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N'-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-N'-(4-fluoro-benzyl)-hydrazinecarboxylic acid tert-butyl ester

There total 4 articles about N'-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-N'-(4-fluoro-benzyl)-hydrazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870-46-2
t-butoxycarbonylhydrazine

: 149267-85-6
N'-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-N'-(4-fluoro-benzyl)-hydrazinecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / ethanol / 3 h / Heating

2: 94 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 0.5 h / 760 Torr / Ambient temperature

3: methanol / 16 h / Heating

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm960022p

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 149267-85-6
N'-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-N'-(4-fluoro-benzyl)-hydrazinecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / ethanol / 3 h / Heating

2: 94 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 0.5 h / 760 Torr / Ambient temperature

3: methanol / 16 h / Heating

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jm960022p

Reference yield:

: N'-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester

: 149267-85-6
N'-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-N'-(4-fluoro-benzyl)-hydrazinecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 0.5 h / 760 Torr / Ambient temperature

2: methanol / 16 h / Heating

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm960022p