8-phenyl-2-(pyridin-4-yl)-6-(2H-tetrazol-5-yl)-4H-chromen-4-one

Base Information

• Chemical Name: 8-phenyl-2-(pyridin-4-yl)-6-(2H-tetrazol-5-yl)-4H-chromen-4-one
• CAS No.: 1450930-11-6
• Molecular Formula: C₂₁H₁₃N₅O₂
• Molecular Weight: 367.367
• Mol file: 1450930-11-6.mol

Synonyms:8-phenyl-2-(pyridin-4-yl)-6-(2H-tetrazol-5-yl)-4H-chromen-4-one

Chemical Property of 8-phenyl-2-(pyridin-4-yl)-6-(2H-tetrazol-5-yl)-4H-chromen-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-phenyl-2-(pyridin-4-yl)-6-(2H-tetrazol-5-yl)-4H-chromen-4-one

There total 5 articles about 8-phenyl-2-(pyridin-4-yl)-6-(2H-tetrazol-5-yl)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-oxo-8-phenyl-2-(pyridin-4-yl)-4H-chromene-6-carbonitrile (1450930-00-3) → 8-phenyl-2-(pyridin-4-yl)-6-(2H-tetrazol-5-yl)-4H-chromen-4-one (1450930-11-6)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; for 72h; Reflux;

DOI:10.1002/cmdc.201200583

Reference yield:

4-cyanophenol (767-00-0) → 8-phenyl-2-(pyridin-4-yl)-6-(2H-tetrazol-5-yl)-4H-chromen-4-one (1450930-11-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: triethylamine / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: aluminum (III) chloride / 3 h / 180 °C

3.1: N-Bromosuccinimide / acetonitrile / 12 h / 20 °C / Inert atmosphere; Darkness

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere

4.2: 12 h / -78 - 20 °C / Inert atmosphere

4.3: 3 h / 80 °C / Inert atmosphere

5.1: potassium carbonate; palladium diacetate / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

6.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 72 h / Reflux

With aluminum (III) chloride; N-Bromosuccinimide; sodium azide; palladium diacetate; potassium carbonate; ammonium chloride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/cmdc.201200583

Reference yield:

4-cyanophenyl acetate (13031-41-9) → 8-phenyl-2-(pyridin-4-yl)-6-(2H-tetrazol-5-yl)-4H-chromen-4-one (1450930-11-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / 3 h / 180 °C

2.1: N-Bromosuccinimide / acetonitrile / 12 h / 20 °C / Inert atmosphere; Darkness

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere

3.2: 12 h / -78 - 20 °C / Inert atmosphere

3.3: 3 h / 80 °C / Inert atmosphere

4.1: potassium carbonate; palladium diacetate / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

5.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 72 h / Reflux

With aluminum (III) chloride; N-Bromosuccinimide; sodium azide; palladium diacetate; potassium carbonate; ammonium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/cmdc.201200583

upstream raw materials:

4-cyanophenol

4-cyanophenyl acetate

2-hydroxy-5-cyanoacetophenone

4-oxo-8-phenyl-2-(pyridin-4-yl)-4H-chromene-6-carbonitrile

Downstream raw materials:

2-methyl-1-(5-(4-oxo-8-phenyl-2-(pyridin-4-yl)-4H-chromen-6-yl)-2H-tetrazol-2-yl)propyl pivalate