2-methyl-1-(5-(4-oxo-8-phenyl-2-(pyridin-4-yl)-4H-chromen-6-yl)-2H-tetrazol-2-yl)propyl pivalate

Base Information

• Chemical Name: 2-methyl-1-(5-(4-oxo-8-phenyl-2-(pyridin-4-yl)-4H-chromen-6-yl)-2H-tetrazol-2-yl)propyl pivalate
• CAS No.: 1450930-13-8
• Molecular Formula: C₃₀H₂₉N₅O₄
• Molecular Weight: 523.591
• Mol file: 1450930-13-8.mol

Synonyms:

Chemical Property of 2-methyl-1-(5-(4-oxo-8-phenyl-2-(pyridin-4-yl)-4H-chromen-6-yl)-2H-tetrazol-2-yl)propyl pivalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-1-(5-(4-oxo-8-phenyl-2-(pyridin-4-yl)-4H-chromen-6-yl)-2H-tetrazol-2-yl)propyl pivalate

There total 8 articles about 2-methyl-1-(5-(4-oxo-8-phenyl-2-(pyridin-4-yl)-4H-chromen-6-yl)-2H-tetrazol-2-yl)propyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

2,2-Dimethylpropanoic acid,1-chloro-2-methylpropyl ester (58304-68-0) + 8-phenyl-2-(pyridin-4-yl)-6-(2H-tetrazol-5-yl)-4H-chromen-4-one (1450930-11-6) → 2-methyl-1-(5-(4-oxo-8-phenyl-2-(pyridin-4-yl)-4H-chromen-6-yl)-2H-tetrazol-2-yl)propyl pivalate (1450930-13-8)

Guidance literature:

With potassium carbonate; In acetonitrile; for 96h; Reflux;

DOI:10.1002/cmdc.201200583

Reference yield:

4-cyanophenyl acetate (13031-41-9) → 2-methyl-1-(5-(4-oxo-8-phenyl-2-(pyridin-4-yl)-4H-chromen-6-yl)-2H-tetrazol-2-yl)propyl pivalate (1450930-13-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: aluminum (III) chloride / 3 h / 180 °C

2.1: N-Bromosuccinimide / acetonitrile / 12 h / 20 °C / Inert atmosphere; Darkness

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere

3.2: 12 h / -78 - 20 °C / Inert atmosphere

3.3: 3 h / 80 °C / Inert atmosphere

4.1: potassium carbonate; palladium diacetate / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

5.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 72 h / Reflux

6.1: potassium carbonate / acetonitrile / 96 h / Reflux

With aluminum (III) chloride; N-Bromosuccinimide; sodium azide; palladium diacetate; potassium carbonate; ammonium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 6.1: |Fischer-Speier Esterification;

DOI:10.1002/cmdc.201200583

Reference yield:

4-cyanophenol (767-00-0) → 2-methyl-1-(5-(4-oxo-8-phenyl-2-(pyridin-4-yl)-4H-chromen-6-yl)-2H-tetrazol-2-yl)propyl pivalate (1450930-13-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: triethylamine / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: aluminum (III) chloride / 3 h / 180 °C

3.1: N-Bromosuccinimide / acetonitrile / 12 h / 20 °C / Inert atmosphere; Darkness

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere

4.2: 12 h / -78 - 20 °C / Inert atmosphere

4.3: 3 h / 80 °C / Inert atmosphere

5.1: potassium carbonate; palladium diacetate / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

6.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 72 h / Reflux

7.1: potassium carbonate / acetonitrile / 96 h / Reflux

With aluminum (III) chloride; N-Bromosuccinimide; sodium azide; palladium diacetate; potassium carbonate; ammonium chloride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 7.1: |Fischer-Speier Esterification;

DOI:10.1002/cmdc.201200583

upstream raw materials:

2,2-Dimethylpropanoic acid,1-chloro-2-methylpropyl ester

8-phenyl-2-(pyridin-4-yl)-6-(2H-tetrazol-5-yl)-4H-chromen-4-one

4-cyanophenol

4-cyanophenyl acetate