(4aR,5S,6R,7R)-2-Benzyl-7-(2-ethyl-hexanoyloxy)-6-methoxy-1-oxo-1,2,3,4,4a,5,6,7-octahydro-isoquinoline-5-carboxylic acid

Base Information

Chemical Name:(4aR,5S,6R,7R)-2-Benzyl-7-(2-ethyl-hexanoyloxy)-6-methoxy-1-oxo-1,2,3,4,4a,5,6,7-octahydro-isoquinoline-5-carboxylic acid
CAS No.:109961-06-0
Molecular Formula:C₂₆H₃₅NO₆
Molecular Weight:457.567
Hs Code.:

Synonyms:(4aR,5S,6R,7R)-2-Benzyl-7-(2-ethyl-hexanoyloxy)-6-methoxy-1-oxo-1,2,3,4,4a,5,6,7-octahydro-isoquinoline-5-carboxylic acid

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Chemical Property of (4aR,5S,6R,7R)-2-Benzyl-7-(2-ethyl-hexanoyloxy)-6-methoxy-1-oxo-1,2,3,4,4a,5,6,7-octahydro-isoquinoline-5-carboxylic acid

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Technology Process of (4aR,5S,6R,7R)-2-Benzyl-7-(2-ethyl-hexanoyloxy)-6-methoxy-1-oxo-1,2,3,4,4a,5,6,7-octahydro-isoquinoline-5-carboxylic acid

There total 4 articles about (4aR,5S,6R,7R)-2-Benzyl-7-(2-ethyl-hexanoyloxy)-6-methoxy-1-oxo-1,2,3,4,4a,5,6,7-octahydro-isoquinoline-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96648-91-8
(4aR^*,5S^*,6S^*,7R^*)-2-benzyl-3,4,4a,5,6,7-hexahydro-5-((methoxymethoxy)methyl)-6,7-oxy-1(2H)-isoquinolone

: 109961-06-0
(4aR,5S,6R,7R)-2-Benzyl-7-(2-ethyl-hexanoyloxy)-6-methoxy-1-oxo-1,2,3,4,4a,5,6,7-octahydro-isoquinoline-5-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / lithium 2-ethylhexanoate / 1,2-dimethoxy-ethane / 16 h / Heating

2: 98 percent / Ag₂O, CaSO₄ / 96 h / Ambient temperature

3: acid / methanol

4: pyridinium dichromate / dimethylformamide

With calcium sulfate; dipyridinium dichromate; lithium 2-ethylhexanoate; silver(l) oxide; acid; In methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00254a036

Reference yield:

: 96648-90-7,109961-10-6
(4aR^*,5S^*)-2-benzyl-5-((methoxymethoxy)methyl)-3,4,4a,5-tetrahydro-1(2H)-isoquinolone

: 109961-06-0
(4aR,5S,6R,7R)-2-Benzyl-7-(2-ethyl-hexanoyloxy)-6-methoxy-1-oxo-1,2,3,4,4a,5,6,7-octahydro-isoquinoline-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 14 h / 0 °C

2: 90 percent / lithium 2-ethylhexanoate / 1,2-dimethoxy-ethane / 16 h / Heating

3: 98 percent / Ag₂O, CaSO₄ / 96 h / Ambient temperature

4: acid / methanol

5: pyridinium dichromate / dimethylformamide

With calcium sulfate; dipyridinium dichromate; lithium 2-ethylhexanoate; 3-chloro-benzenecarboperoxoic acid; silver(l) oxide; acid; In methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00254a036

Reference yield:

: 96648-93-0
(4aR^*,5S^*,6S^*,7S^*)-2-benzyl-7-((2'-ethylhexanoyl)oxy)-3,4,4a,5,6,7-hexahydro-6-methoxy-5-((methoxymethoxy)methyl)-1(2H)-isoquinolone

: 109961-06-0
(4aR,5S,6R,7R)-2-Benzyl-7-(2-ethyl-hexanoyloxy)-6-methoxy-1-oxo-1,2,3,4,4a,5,6,7-octahydro-isoquinoline-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: acid / methanol

2: pyridinium dichromate / dimethylformamide

With dipyridinium dichromate; acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/ja00254a036