(3aR,7R,7aS)-5-(4-methoxybenzyl)-7-methylhexahydrooxazolo[4,5-c]pyridin-2(3H)-one

Base Information

Chemical Name:(3aR,7R,7aS)-5-(4-methoxybenzyl)-7-methylhexahydrooxazolo[4,5-c]pyridin-2(3H)-one
CAS No.:1187056-30-9
Molecular Formula:C₁₅H₂₀N₂O₃
Molecular Weight:276.335
Hs Code.:

Synonyms:(3aR,7R,7aS)-5-(4-methoxybenzyl)-7-methylhexahydrooxazolo[4,5-c]pyridin-2(3H)-one

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Chemical Property of (3aR,7R,7aS)-5-(4-methoxybenzyl)-7-methylhexahydrooxazolo[4,5-c]pyridin-2(3H)-one

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Technology Process of (3aR,7R,7aS)-5-(4-methoxybenzyl)-7-methylhexahydrooxazolo[4,5-c]pyridin-2(3H)-one

There total 6 articles about (3aR,7R,7aS)-5-(4-methoxybenzyl)-7-methylhexahydrooxazolo[4,5-c]pyridin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1187056-29-6
2-((4R)-2-oxo-4-(tosyloxymethyl)oxazolidin-5-yl)-propyl 4-methylbenzenesulfonate

: 2393-23-9
4-methoxy-benzylamine

: 1187056-31-0
(3aR,7S,7aR)-5-(4-methoxybenzyl)-7-methylhexahydrooxazolo[4,5-c]pyridin-2(3H)-one

: 1187056-30-9
(3aR,7R,7aS)-5-(4-methoxybenzyl)-7-methylhexahydrooxazolo[4,5-c]pyridin-2(3H)-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 14h;

Reference yield:

: 1187056-25-2
(4R)-4-(benzyloxymethyl)-5-(but-3-en-2-yl)oxazolidin-2-one

: 1187056-30-9
(3aR,7R,7aS)-5-(4-methoxybenzyl)-7-methylhexahydrooxazolo[4,5-c]pyridin-2(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium periodate / osmium(VIII) oxide / methanol; water / 3 h

2.1: sodium tetrahydroborate / ethanol / 15 h / 0 - 20 °C

2.2: 0.33 h

3.1: hydrogen / palladium 10% on activated carbon / methanol / 15 h

4.1: pyridine / 14 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 14 h / 100 °C

With pyridine; sodium tetrahydroborate; sodium periodate; hydrogen; N-ethyl-N,N-diisopropylamine; osmium(VIII) oxide; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; water;

Reference yield:

: 1187056-24-1
tert-butyl (2R)-1-(benzyloxy)-3-hydroxy-4-methylhex-5-en-2-ylcarbamate

: 1187056-30-9
(3aR,7R,7aS)-5-(4-methoxybenzyl)-7-methylhexahydrooxazolo[4,5-c]pyridin-2(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 72 h

2.1: sodium periodate / osmium(VIII) oxide / methanol; water / 3 h

3.1: sodium tetrahydroborate / ethanol / 15 h / 0 - 20 °C

3.2: 0.33 h

4.1: hydrogen / palladium 10% on activated carbon / methanol / 15 h

5.1: pyridine / 14 h / 0 - 20 °C

6.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 14 h / 100 °C

With pyridine; sodium tetrahydroborate; sodium periodate; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; osmium(VIII) oxide; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; mineral oil;