6-(4-bromo-phenyl)-5-(4-chloro-phenyl)-1-[3-(2,5-dimethyl-pyrrole-1-sulfonyl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

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Chemical Name:6-(4-bromo-phenyl)-5-(4-chloro-phenyl)-1-[3-(2,5-dimethyl-pyrrole-1-sulfonyl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one
CAS No.:954146-98-6
Molecular Formula:C₂₉H₂₁BrClN₅O₃S
Molecular Weight:634.94
Hs Code.:

Synonyms:6-(4-bromo-phenyl)-5-(4-chloro-phenyl)-1-[3-(2,5-dimethyl-pyrrole-1-sulfonyl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

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Chemical Property of 6-(4-bromo-phenyl)-5-(4-chloro-phenyl)-1-[3-(2,5-dimethyl-pyrrole-1-sulfonyl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

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Technology Process of 6-(4-bromo-phenyl)-5-(4-chloro-phenyl)-1-[3-(2,5-dimethyl-pyrrole-1-sulfonyl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

There total 10 articles about 6-(4-bromo-phenyl)-5-(4-chloro-phenyl)-1-[3-(2,5-dimethyl-pyrrole-1-sulfonyl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 954145-68-7
3-[6-(4-bromo-phenyl)-5-(4-chloro-phenyl)-4-oxo-4,5-dihydro-pyrazolo[3,4-d]pyrimidin-1-yl]-benzenesulfonamide

: 110-13-4
2,5-hexanedione

: 954146-98-6
6-(4-bromo-phenyl)-5-(4-chloro-phenyl)-1-[3-(2,5-dimethyl-pyrrole-1-sulfonyl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 18h; Heating / reflux;

Reference yield:

: 954146-94-2
5-amino-1-(3-methylsulfanyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

: 954146-98-6
6-(4-bromo-phenyl)-5-(4-chloro-phenyl)-1-[3-(2,5-dimethyl-pyrrole-1-sulfonyl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 8 steps

1: 6 h / 170 °C / Heating / reflux

2: Monoperoxyphthalic acid, magnesium salt / methanol; dichloromethane / 1 h / 0 °C

3: sodium acetate / 5 h / Heating / reflux

4: Monoperoxyphthalic acid, magnesium salt / methanol; dichloromethane / 2 h / 0 - 20 °C

5: methanol; sodium hydroxide; water / tetrahydrofuran / 1.5 h / 0 °C

6: sulfuryl dichloride / dichloromethane / 1.5 h / 0 °C

7: ammonia / tetrahydrofuran; water / 0.75 h / 0 °C

8: toluene-4-sulfonic acid / toluene / 18 h / Heating / reflux

With methanol; sodium hydroxide; sulfuryl dichloride; ammonia; water; sodium acetate; toluene-4-sulfonic acid; Monoperoxyphthalic acid, magnesium salt; In tetrahydrofuran; methanol; dichloromethane; water; toluene;

Reference yield:

: 106-47-8
4-chloro-aniline

: 954146-98-6
6-(4-bromo-phenyl)-5-(4-chloro-phenyl)-1-[3-(2,5-dimethyl-pyrrole-1-sulfonyl)-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one

Guidance literature:: Multi-step reaction with 10 steps

1: sodium hydroxide; triethylamine / dichloromethane; water / 1 h / 20 °C

2: thionyl chloride / 1 - 2 h / 80 °C / Heating / reflux

3: 6 h / 170 °C / Heating / reflux

4: Monoperoxyphthalic acid, magnesium salt / methanol; dichloromethane / 1 h / 0 °C

5: sodium acetate / 5 h / Heating / reflux

6: Monoperoxyphthalic acid, magnesium salt / methanol; dichloromethane / 2 h / 0 - 20 °C

7: methanol; sodium hydroxide; water / tetrahydrofuran / 1.5 h / 0 °C

8: sulfuryl dichloride / dichloromethane / 1.5 h / 0 °C

9: ammonia / tetrahydrofuran; water / 0.75 h / 0 °C

10: toluene-4-sulfonic acid / toluene / 18 h / Heating / reflux

With methanol; sodium hydroxide; thionyl chloride; sulfuryl dichloride; ammonia; water; sodium acetate; toluene-4-sulfonic acid; Monoperoxyphthalic acid, magnesium salt; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; toluene;