2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-difluoro-indan-2-carboxylic acid ethyl ester

Base Information

Chemical Name:2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-difluoro-indan-2-carboxylic acid ethyl ester
CAS No.:1092447-72-7
Molecular Formula:C₂₄H₂₅F₂NO₄
Molecular Weight:429.464
Hs Code.:

Synonyms:2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-difluoro-indan-2-carboxylic acid ethyl ester

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Chemical Property of 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-difluoro-indan-2-carboxylic acid ethyl ester

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Technology Process of 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-difluoro-indan-2-carboxylic acid ethyl ester

There total 7 articles about 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-difluoro-indan-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1092447-71-6
2-amino-5,6-difluoro-indan-2-carboxylic acid ethyl ester

: 1092447-98-7
2-cyclobutoxy-3-methyl-benzoic acid

: 1092447-72-7
2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-difluoro-indan-2-carboxylic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 23287-26-5
3-methylsalicylic acid methyl ester

: 1092447-72-7
2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-difluoro-indan-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / potassium iodide / N,N-dimethyl-formamide / 96 h / 43 °C

2.1: methanol; lithium hydroxide; water / 1,4-dioxane / 18 h

2.2: pH 2

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With methanol; lithium hydroxide; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium iodide; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 915944-27-3
1,2-bis(bromomethyl)-4,5-difluorobenzene

: 1092447-72-7
2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-difluoro-indan-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / acetonitrile / 3 h / Heating / reflux

2.1: hydrogenchloride; water / ethanol / 1 h / 20 °C

2.2: 10 °C / pH 9 - 10

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; water; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; N,N-dimethyl-formamide; acetonitrile;