915944-27-3

Basic information

• Product Name: 1,2-Bis(bromomethyl)-4,5-difluorobenzene
• Synonyms: 1,2-Bis(bromomethyl)-4,5-difluorobenzene
• CAS NO: 915944-27-3
• Molecular Formula: C₈H₆Br₂F₂
• Molecular Weight: 299.9380464
• Mol File: 915944-27-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 272℃
• Flash Point: 118℃
• Appearance: /
• Density: 1.912
• CAS DataBase Reference: 1,2-Bis(bromomethyl)-4,5-difluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Bis(bromomethyl)-4,5-difluorobenzene(915944-27-3)
• EPA Substance Registry System: 1,2-Bis(bromomethyl)-4,5-difluorobenzene(915944-27-3)

Safety Data

• Hazardous Substances Data: 915944-27-3(Hazardous Substances Data)

Usage

Physical state

Colorless liquid

Usage

Commonly used in organic synthesis and chemical research

Chemical classification

Derivative of benzene

Substituents

Bromine and fluorine attached to the benzene ring

Reactivity

Known for its reactivity

Application

Used as a building block in the synthesis of complex organic molecules

Industrial use

Precursor in the production of pharmaceuticals and agrochemicals

Safety precautions

Toxic and may cause skin and eye irritation; handle with caution

Upstream product

• 18959-32-5 dimethyl 4,5-difluorophthalate 
• 18959-31-4 4,5-difluorophthalic acid 
• 854519-97-4 (4,5-difluoro-1,2-phenylene)dimethanol 

Downstream Products

• 1229615-06-8 2-(benzhydrylidene-amino)-5,6-difluoroindan-2-carboxylic acid ethyl ester 
• 1092447-71-6 2-amino-5,6-difluoro-indan-2-carboxylic acid ethyl ester 
• 1092447-91-0 5,6-difluoro-2-(2-iodo-3-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester 
• 1092445-77-6 5,6-difluoro-2-(3-methyl-2-propyl-benzoylamino)indan-2-carboxylic acid 
• 1092445-74-3 5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid 
• 1092447-92-1 5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid ethyl ester 
• 1092445-75-4 5,6-difluoro-2-(2-isobutyl-3-methyl-benzoylamino)-indan-2-carboxylic acid 
• 1092445-55-0 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-difluoro-indan-2-carboxylic acid 
• 1092447-72-7 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-difluoro-indan-2-carboxylic acid ethyl ester 

Relevant articles and documents

COMBINATION THERAPY

The invention provides a combinations and pharmaceutical compositions comprising (i) a compound which is an indane according to Formula (I) or a pharmaceutically acceptable salt thereof; and (ii) one or more CFTR modulator; wherein R1, R2

INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION

The invention relates to a compound which is an indane according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, L, M, ?, n, p, and q are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics.

SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS

The present invention relates to A compound of the formula Ia wherein in any of its stereoisomers forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, wherein the substituents are as described herein. The inventive compounds have CXCR5 inhibitory activity are particularly useful in treating or preventing various inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, lupus, Crohn's Disease, associated with the modulation of the human CXCR5 receptor.