915944-27-3

Usage

Physical state

Colorless liquid

Usage

Commonly used in organic synthesis and chemical research

Chemical classification

Derivative of benzene

Substituents

Bromine and fluorine attached to the benzene ring

Reactivity

Known for its reactivity

Application

Used as a building block in the synthesis of complex organic molecules

Industrial use

Precursor in the production of pharmaceuticals and agrochemicals

Safety precautions

Toxic and may cause skin and eye irritation; handle with caution

Upstream product

• 18959-32-5 dimethyl 4,5-difluorophthalate 
• 18959-31-4 4,5-difluorophthalic acid 
• 854519-97-4 (4,5-difluoro-1,2-phenylene)dimethanol 

Downstream Products

• 1092447-72-7 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-difluoro-indan-2-carboxylic acid ethyl ester 
• 1092445-55-0 2-(2-cyclobutyloxy-3-methyl-benzoylamino)-5,6-difluoro-indan-2-carboxylic acid 
• 1092445-75-4 5,6-difluoro-2-(2-isobutyl-3-methyl-benzoylamino)-indan-2-carboxylic acid 
• 1092445-74-3 5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid 
• 1092447-92-1 5,6-difluoro-2-[3-methyl-2-(2-methyl-propenyl)-benzoylamino]-indan-2-carboxylic acid ethyl ester 
• 1092445-77-6 5,6-difluoro-2-(3-methyl-2-propyl-benzoylamino)indan-2-carboxylic acid 
• 1092447-91-0 5,6-difluoro-2-(2-iodo-3-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester 
• 1092447-71-6 2-amino-5,6-difluoro-indan-2-carboxylic acid ethyl ester 
• 1229615-06-8 2-(benzhydrylidene-amino)-5,6-difluoroindan-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

COMBINATION THERAPY

The invention provides a combinations and pharmaceutical compositions comprising (i) a compound which is an indane according to Formula (I) or a pharmaceutically acceptable salt thereof; and (ii) one or more CFTR modulator; wherein R1, R2

INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION

The invention relates to a compound which is an indane according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, n and p are as defined herein

INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION

The invention relates to a compound which is an indane according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, L, M, ?, n, p, and q are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics.

CHEMICAL COMPOUNDS AS ANTIBIOTICS

The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p? q, L, ?, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.

SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS

The present invention relates to A compound of the formula Ia wherein in any of its stereoisomers forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, wherein the substituents are as described herein. The inventive compounds have CXCR5 inhibitory activity are particularly useful in treating or preventing various inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, lupus, Crohn's Disease, associated with the modulation of the human CXCR5 receptor.

PYRAN/DIOXAN DERIVATIVES AND USE THEREOF IN LIQUID CRYSTAL MEDIA

The invention relates to pyran/dioxan derivatives and use thereof as components in liquid crystal media. The invention further relates to liquid crystal and electrooptical display elements, comprising said liquid crystal media.

Indanyl-piperazine compounds

A compound selected from those of formula (I): wherein: R3 represents a hydrogen atom, and R1 and R2 together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, ?or R1 represents a hydrogen atom, and R2 and R3 together with the carbon atoms carrying them form a benzene, naphthalene or quinoline ring structure, each of the ring structures being optionally substituted, n represents 1 or 2, —X— represents a group selected from —(CH2)m—O-Ak-, —(CH2)m—NR4-Ak-, —(CO)—NR4-Ak- and —(CH2)m—NR4-(CO)—, ?m represents an integer between 1 and 6 inclusive, Ak represents an optionally substituted alkylene chain, and R4 represents a hydrogen atom or an alkyl group, Ar represents an aryl or heteroaryl group, its enantiomers, diasteroisomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.