2-[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]thioacetamide

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Chemical Name:2-[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]thioacetamide
CAS No.:1314841-50-3
Molecular Formula:C₂₀H₂₀F₃N₃O₂S₂
Molecular Weight:455.525
Hs Code.:

Synonyms:2-[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]thioacetamide

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Chemical Property of 2-[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]thioacetamide

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Technology Process of 2-[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]thioacetamide

There total 6 articles about 2-[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]thioacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1314841-49-0
[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]acetonitrile

: 1314841-50-3
2-[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]thioacetamide

Guidance literature:: With O,O-Diethyl hydrogen phosphorodithioate; In tetrahydrofuran; at 100 ℃; for 4h;

Reference yield:

: 1314186-71-4
3-(1,1-dimethylethyl)-N-(2-iodo-6-trifluoromethylpyridin-3-yl)benzenesulfonamide

: 1314841-50-3
2-[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]thioacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.17 h / 120 °C / Microwave irradiation

2: phosphorus tribromide / dichloromethane / 96 h / 20 °C

3: tetrabutylammomium bromide / dichloromethane; water / 72 h / 20 °C

4: O,O-Diethyl hydrogen phosphorodithioate / tetrahydrofuran / 4 h / 100 °C

With copper(l) iodide; tetrabutylammomium bromide; phosphorus tribromide; O,O-Diethyl hydrogen phosphorodithioate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 2905-26-2
3-(tert-butyl)benzene-1-sulfonyl chloride

: 1314841-50-3
2-[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]thioacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / 20 °C

1.2: 1 h / Reflux

2.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.17 h / 120 °C / Microwave irradiation

3.1: phosphorus tribromide / dichloromethane / 96 h / 20 °C

4.1: tetrabutylammomium bromide / dichloromethane; water / 72 h / 20 °C

5.1: O,O-Diethyl hydrogen phosphorodithioate / tetrahydrofuran / 4 h / 100 °C

With pyridine; copper(l) iodide; tetrabutylammomium bromide; phosphorus tribromide; O,O-Diethyl hydrogen phosphorodithioate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;