[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]acetonitrile

Base Information

Chemical Name:[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]acetonitrile
CAS No.:1314841-49-0
Molecular Formula:C₂₀H₁₈F₃N₃O₂S
Molecular Weight:421.443
Hs Code.:

Synonyms:[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]acetonitrile

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Chemical Property of [1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]acetonitrile

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Technology Process of [1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]acetonitrile

There total 5 articles about [1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: potassium cyanide

: 1314841-36-5
2-bromomethyl-1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoro-methyl-1H-pyrrolo[3,2-b]pyridine

: 1314841-49-0
[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]acetonitrile

Guidance literature:: With tetrabutylammomium bromide; In dichloromethane; water; at 20 ℃; for 72h;

Reference yield:

: 2905-26-2
3-(tert-butyl)benzene-1-sulfonyl chloride

: 1314841-49-0
[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 20 °C

1.2: 1 h / Reflux

2.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.17 h / 120 °C / Microwave irradiation

3.1: phosphorus tribromide / dichloromethane / 96 h / 20 °C

4.1: tetrabutylammomium bromide / dichloromethane; water / 72 h / 20 °C

With pyridine; copper(l) iodide; tetrabutylammomium bromide; phosphorus tribromide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 920979-04-0
2-iodo-6-(trifluoromethyl)pyridin-3-amine

: 1314841-49-0
[1-(3-(1,1-dimethylethyl)phenylsulfonyl)-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridin-2-yl]acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 20 °C

1.2: 1 h / Reflux

2.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.17 h / 120 °C / Microwave irradiation

3.1: phosphorus tribromide / dichloromethane / 96 h / 20 °C

4.1: tetrabutylammomium bromide / dichloromethane; water / 72 h / 20 °C

With pyridine; copper(l) iodide; tetrabutylammomium bromide; phosphorus tribromide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; water; N,N-dimethyl-formamide;