Technology Process of 4,4,9,9-tetra(benzyloxymethyl)dodec-11-ene-1,6-diyne
There total 4 articles about 4,4,9,9-tetra(benzyloxymethyl)dodec-11-ene-1,6-diyne which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4,4,9,9-tetra(hydroxymethyl)dodec-11-ene-1,6-diyne;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
benzyl bromide;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 3h;
Further stages.;
DOI:10.1021/ja993977g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: LiAlH4 / diethyl ether / 20 h / 20 °C
2.1: NaH / dimethylformamide; various solvent(s) / 1 h / 20 °C
2.2: 70 percent / dimethylformamide; various solvent(s) / 3 h / 20 °C
With
lithium aluminium tetrahydride; sodium hydride;
In
diethyl ether; N,N-dimethyl-formamide;
1.1: Reduction / 2.1: Metallation / 2.2: Etherification;
DOI:10.1021/ja993977g
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaH / tetrahydrofuran; various solvent(s) / 1 h / 22 °C
1.2: 79 percent / tetrahydrofuran; various solvent(s) / 2 h / 22 °C
2.1: NaH / tetrahydrofuran; various solvent(s) / 1 h / 20 °C
2.2: 85 percent / tetrahydrofuran; various solvent(s) / 3 h / 20 °C
3.1: LiAlH4 / diethyl ether / 20 h / 20 °C
4.1: NaH / dimethylformamide; various solvent(s) / 1 h / 20 °C
4.2: 70 percent / dimethylformamide; various solvent(s) / 3 h / 20 °C
With
lithium aluminium tetrahydride; sodium hydride;
In
tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
1.1: Metallation / 1.2: Alkylation / 2.1: Metallation / 2.2: Alkylation / 3.1: Reduction / 4.1: Metallation / 4.2: Etherification;
DOI:10.1021/ja993977g
