(2-methylphenyl)(1-(pyrimidin-2-yl)-1H-pyrrol-2-yl)methanone

Base Information

• Chemical Name: (2-methylphenyl)(1-(pyrimidin-2-yl)-1H-pyrrol-2-yl)methanone
• CAS No.: 1610885-87-4
• Molecular Formula: C₁₆H₁₃N₃O
• Molecular Weight: 263.299
• Mol file: 1610885-87-4.mol

Synonyms:(2-methylphenyl)(1-(pyrimidin-2-yl)-1H-pyrrol-2-yl)methanone

Chemical Property of (2-methylphenyl)(1-(pyrimidin-2-yl)-1H-pyrrol-2-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (2-methylphenyl)(1-(pyrimidin-2-yl)-1H-pyrrol-2-yl)methanone

There total 1 articles about (2-methylphenyl)(1-(pyrimidin-2-yl)-1H-pyrrol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ortho-methylphenyl iodide (615-37-2) + carbon monoxide (201230-82-2) + 2-pyrrol-1-yl-pyrimidine (114646-17-2) → (2-methylphenyl)(1-(pyrimidin-2-yl)-1H-pyrrol-2-yl)methanone (1610885-87-4)

Guidance literature:

With potassium acetate; sodium hydrogencarbonate; In water; at 120 ℃; for 20h; under 22502.3 Torr; regioselective reaction; Inert atmosphere; Autoclave;

DOI:10.1002/chem.201304314

Reference yield: 91.0%

(2-methylphenyl)(1-(pyrimidin-2-yl)-1H-pyrrol-2-yl)methanone (1610885-87-4) → (1H-pyrrol-2-yl)(o-tolyl)methanone (91568-90-0)

Guidance literature:

With sodium ethanolate; In dimethyl sulfoxide; at 100 ℃; for 5h; Inert atmosphere;

DOI:10.1002/chem.201304314

upstream raw materials:

ortho-methylphenyl iodide

carbon monoxide

2-pyrrol-1-yl-pyrimidine

Downstream raw materials:

(1H-pyrrol-2-yl)(o-tolyl)methanone