Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 4-{3-tert-butyl-5-[((E)-(1R,2R)-2-{[1-(3,5-di-tert-butyl-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-cyclohexylimino)-methyl]-4-hydroxy-phenylethynyl}-phenyl ester

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Chemical Name:Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 4-{3-tert-butyl-5-[((E)-(1R,2R)-2-{[1-(3,5-di-tert-butyl-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-cyclohexylimino)-methyl]-4-hydroxy-phenylethynyl}-phenyl ester
CAS No.:910481-25-3
Molecular Formula:C₄₈H₅₈N₂O₄
Molecular Weight:727
Hs Code.:

Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 4-{3-tert-butyl-5-[((E)-(1R,2R)-2-{[1-(3,5-di-tert-butyl-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-cyclohexylimino)-methyl]-4-hydroxy-phenylethynyl}-phenyl ester

Synonyms:Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 4-{3-tert-butyl-5-[((E)-(1R,2R)-2-{[1-(3,5-di-tert-butyl-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-cyclohexylimino)-methyl]-4-hydroxy-phenylethynyl}-phenyl ester

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Chemical Property of Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 4-{3-tert-butyl-5-[((E)-(1R,2R)-2-{[1-(3,5-di-tert-butyl-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-cyclohexylimino)-methyl]-4-hydroxy-phenylethynyl}-phenyl ester

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Technology Process of Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 4-{3-tert-butyl-5-[((E)-(1R,2R)-2-{[1-(3,5-di-tert-butyl-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-cyclohexylimino)-methyl]-4-hydroxy-phenylethynyl}-phenyl ester

There total 7 articles about Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 4-{3-tert-butyl-5-[((E)-(1R,2R)-2-{[1-(3,5-di-tert-butyl-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-cyclohexylimino)-methyl]-4-hydroxy-phenylethynyl}-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 886055-59-0
(R,R)-N-(3,5-di-tert-butylsalicylidene)-N'-[3-tert-butyl-5-(4'-hydroxyphenylethynyl)salicylidene]-1,2-cyclohexanediamine

: 27063-48-5,34733-86-3,37750-50-8,117835-14-0,143916-13-6,214920-46-4,783334-78-1
bicyclo[2.2.1]hept-2-ene-5-carbonyl chloride

: 910481-25-3
Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 4-{3-tert-butyl-5-[((E)-(1R,2R)-2-{[1-(3,5-di-tert-butyl-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-cyclohexylimino)-methyl]-4-hydroxy-phenylethynyl}-phenyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 88-18-6
2-tert-Butylphenol

: 910481-25-3
Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 4-{3-tert-butyl-5-[((E)-(1R,2R)-2-{[1-(3,5-di-tert-butyl-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-cyclohexylimino)-methyl]-4-hydroxy-phenylethynyl}-phenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 90 percent / Br₂ / CH₂Cl₂ / -10 - 20 °C

2.1: CF₃CO₂H / 20 h / 115 °C

2.2: 79 percent / CF₃CO₂H; aq. H₂SO₄ / 1 h / Heating

3.1: 88 percent / PdCl₂(PPh₃)2; CuI; Et₃N / PPh₃ / tetrahydrofuran / 6 h / Heating

4.1: 85 percent / TBAF*H₂O; aq. HCl / tetrahydrofuran / 24 h / 0 - 20 °C

5.1: 51 percent / PdCl₂(PPh₃)2; CuI; Et₃N / PPh₃ / tetrahydrofuran / 27 h / 20 °C

6.1: 4 Angstroem molecular sieves / ethanol; methanol / 4 h / 20 °C

6.2: 64 percent / Et₃N; 4 Angstroem molecular sieves / ethanol; methanol; CH₂Cl₂ / 4 h / 20 °C

7.1: Et₃N / CH₂Cl₂ / 1 h / 0 - 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 4 A molecular sieve; tetrabutyl ammonium fluoride; bromine; triethylamine; trifluoroacetic acid; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; 3.1: Sonogashira coupling / 5.1: Sonogashira coupling;
DOI:10.1021/jo051919+

Reference yield:

: 10323-39-4
4-bromo-2-tert-butylphenol

: 910481-25-3
Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 4-{3-tert-butyl-5-[((E)-(1R,2R)-2-{[1-(3,5-di-tert-butyl-2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-cyclohexylimino)-methyl]-4-hydroxy-phenylethynyl}-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: CF₃CO₂H / 20 h / 115 °C

1.2: 79 percent / CF₃CO₂H; aq. H₂SO₄ / 1 h / Heating

2.1: 88 percent / PdCl₂(PPh₃)2; CuI; Et₃N / PPh₃ / tetrahydrofuran / 6 h / Heating

3.1: 85 percent / TBAF*H₂O; aq. HCl / tetrahydrofuran / 24 h / 0 - 20 °C

4.1: 51 percent / PdCl₂(PPh₃)2; CuI; Et₃N / PPh₃ / tetrahydrofuran / 27 h / 20 °C

5.1: 4 Angstroem molecular sieves / ethanol; methanol / 4 h / 20 °C

5.2: 64 percent / Et₃N; 4 Angstroem molecular sieves / ethanol; methanol; CH₂Cl₂ / 4 h / 20 °C

6.1: Et₃N / CH₂Cl₂ / 1 h / 0 - 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 4 A molecular sieve; tetrabutyl ammonium fluoride; triethylamine; trifluoroacetic acid; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; 2.1: Sonogashira coupling / 4.1: Sonogashira coupling;
DOI:10.1021/jo051919+