(S)-3,6-Bis(benzyloxy)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxybenzamide

Base Information

Chemical Name:(S)-3,6-Bis(benzyloxy)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxybenzamide
CAS No.:101460-68-8
Molecular Formula:C₂₉H₃₄N₂O₄
Molecular Weight:474.6
Hs Code.:

Synonyms:(S)-3,6-Bis(benzyloxy)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxybenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3,6-Bis(benzyloxy)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxybenzamide

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Technology Process of (S)-3,6-Bis(benzyloxy)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxybenzamide

There total 7 articles about (S)-3,6-Bis(benzyloxy)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 3,6-Bis-benzyloxy-2-methoxy-benzoyl chloride

: 22795-99-9
(S)-2-(Aminomethyl)-1-ethylpyrrolidine

: 101460-68-8
(S)-3,6-Bis(benzyloxy)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxybenzamide

Guidance literature:: In chloroform; at 50 ℃; for 0.5h;
DOI:10.1021/jm00166a012

Reference yield:

: 3,6-dibenzyloxy-2-methoxybenzamide acid

: 22795-99-9
(S)-2-(Aminomethyl)-1-ethylpyrrolidine

: 101460-68-8
(S)-3,6-Bis(benzyloxy)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxybenzamide

Guidance literature:: With thionyl chloride; N-methyl-acetamide; In dichloromethane; toluene;

Reference yield:

: 824-46-4
methoxyhydroquinone

: 101460-68-8
(S)-3,6-Bis(benzyloxy)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: trichloroacetic acid / CH₂Cl₂ / 96 h / Ambient temperature

3: aq. NaOH / dimethylformamide / 60 °C

4: aq. NaOH / ethanol; dioxane / 1) 80 deg C, 5 h, 2) rt, overnight

5: SOCl₂, DMF / toluene / 1.5 h / 60 °C

6: CH₂Cl₂

With sodium hydroxide; thionyl chloride; N,N-dimethyl-formamide; trichloroacetic acid; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00065a015