2-Methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde

Base Information

• Chemical Name: 2-Methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde
• CAS No.: 163041-68-7
• Molecular Formula: C13H16O4
• Molecular Weight: 236.268
• DSSTox Substance ID: DTXSID60398758
• Mol file: 163041-68-7.mol

Synonyms:163041-68-7;2-Methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde;2-methoxy-4-(oxan-2-yloxy)benzaldehyde;4-Tetrahydropyranoxy-2-methoxybenzaldehyde;2-methoxy-4-(tetrahydro-pyran-2-yloxy)-benzaldehyde;SCHEMBL5863561;DTXSID60398758;XDLKXYRFRQWAJD-UHFFFAOYSA-N;MFCD03426334;AKOS015911460;2-Methoxy-4-[(oxan-2-yl)oxy]benzaldehyde;4-Tetrahydroxypyranoxy-2-methoxybenzaldehyde;FT-0643575;4-tetrahydropyranoxy-2-methoxybenzaldehyde, AldrichCPR;2-methoxy-4-(tetrahydro-2H-pyran-2-yloxy)benzaldehyde;BENZALDEHYDE,2-METHOXY-4-[(TETRAHYDRO-2H-PYRAN-2-YL)OXY]-

Chemical Property of 2-Methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde

Chemical Property:

• Vapor Pressure: 1E-06mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 403.7 °C at 760 mmHg
• Flash Point: 181.1 °C
• PSA: 44.76000
• Density: 1.165 g/cm³
• LogP: 2.41310
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 236.10485899
• Heavy Atom Count: 17
• Complexity: 244

Purity/Quality:

98%min ^*data from raw suppliers

2-Methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)OC2CCCCO2)C=O

Technology Process of 2-Methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde

There total 2 articles about 2-Methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

3,4-dihydro-2H-pyran (110-87-2) + 4-hydroxy-2-methoxybenzaldehyde (18278-34-7) → 2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde (163041-68-7)

Guidance literature:

With 5A molecular sieve; pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃;

Reference yield:

→ 2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde (163041-68-7)

Guidance literature:

Reference yield: 67.1%

2-Acetylthiophene (88-15-3,97511-16-5) + 2-methoxy-4-((tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde (163041-68-7) → (E)-3-(4-hydroxy-2-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one (1352443-66-3)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 12h;

DOI:10.5012/bkcs.2011.32.9.3459

upstream raw materials:

3,4-dihydro-2H-pyran

4-hydroxy-2-methoxybenzaldehyde

Downstream raw materials:

[2-methoxy-4-(tetrahydro-pyran-2-yloxy)-benzyl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

C₂₆H₃₀O₆

(E)-1-(furan-2-yl)-3-(4-hydroxy-2-methoxyphenyl)prop-2-en-1-one

(E)-3-(4-hydroxy-2-methoxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one

Refernces

• 1、 -. "Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones". . . Retrieved 2008/06/13.