4-Hydroxy-2-methoxybenzaldehyde

Base Information

• Chemical Name: 4-Hydroxy-2-methoxybenzaldehyde
• CAS No.: 18278-34-7
• Molecular Formula: C8H8O3
• Molecular Weight: 152.15
• Hs Code.: 29124990
• Mol file: 18278-34-7.mol

Synonyms:4-Hydroxy-o-anisaldehyde;

Chemical Property of 4-Hydroxy-2-methoxybenzaldehyde

Chemical Property:

• Appearance/Colour: light-yellow crystalline powder
• Vapor Pressure: 0.000279mmHg at 25°C
• Melting Point: 158-161 °C
• Refractive Index: 1.587
• Boiling Point: 312.9 °C at 760 mmHg
• PKA: 7.40±0.18(Predicted)
• Flash Point: 132.3 °C
• PSA: 46.53000
• Density: 1.231 g/cm³
• LogP: 1.21330
• Storage Temp.: Store at 0°C
• Sensitive.: Air Sensitive
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: practically insoluble

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

4-Hydroxy-2-methoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39-6-36/37/39-27

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: A useful intermediate in the sythesis of solid phase supports for the preparation of fully protected peptide fragments. 4-Hydroxy-2-methoxybenzaldehyde is a useful intermediate in the sythesis of solid phase supports for the preparation of fully protected peptide fragments

Technology Process of 4-Hydroxy-2-methoxybenzaldehyde

There total 27 articles about 4-Hydroxy-2-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-benzoyloxy-2-methoxy-benzaldehyde (403477-22-5) → 4-hydroxy-2-methoxybenzaldehyde (18278-34-7)

Guidance literature:

With potassium fluoride; thiophenol; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 1h;

DOI:10.1021/jo0163039

Reference yield: 90.0%

4-acetoxy-2-methoxy-benzaldehyde (67395-05-5) → 4-hydroxy-2-methoxybenzaldehyde (18278-34-7)

Guidance literature:

With potassium fluoride; thiophenol; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 1h;

DOI:10.1021/jo0163039

Reference yield: 88.2%

2-methoxy-4-(methoxylmethoxy)benzaldehyde (114628-32-9) → 4-hydroxy-2-methoxybenzaldehyde (18278-34-7)

Guidance literature:

With hydrogenchloride; water; In methanol; at 20 ℃;

DOI:10.1016/j.bmcl.2014.05.099

upstream raw materials:

formaldehyd

O-methylresorcine

hydrogen cyanide

chloroform

Downstream raw materials:

4-ethoxy-2-methoxyphenyl formate

4-acetoxy-2-methoxy-benzaldehyde

4-hydroxy-2-methoxy-benzaldehyde-oxime

3,5-dibromo-4-hydroxy-2-methoxybenzaldehyde

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