N-{(1R)-1-(5-Amino-1,3,4-oxadiazol-2-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide

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Chemical Name:N-{(1R)-1-(5-Amino-1,3,4-oxadiazol-2-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide
CAS No.:1268634-82-7
Molecular Formula:C₂₄H₂₀ClF₆N₇O₄
Molecular Weight:619.911
Hs Code.:

N-{(1R)-1-(5-Amino-1,3,4-oxadiazol-2-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide

Synonyms:N-{(1R)-1-(5-Amino-1,3,4-oxadiazol-2-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide

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Chemical Property of N-{(1R)-1-(5-Amino-1,3,4-oxadiazol-2-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide

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Technology Process of N-{(1R)-1-(5-Amino-1,3,4-oxadiazol-2-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide

There total 9 articles about N-{(1R)-1-(5-Amino-1,3,4-oxadiazol-2-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 506-68-3
bromocyane

: 1268635-51-3
2-{3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}-N-{(2R)-1-hydrazino-1-oxo-2-[3-(trifluoromethyl)phenyl]propan-2-yl}acetamide

: 1268634-82-7
N-{(1R)-1-(5-Amino-1,3,4-oxadiazol-2-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide

Guidance literature:: In methanol; at 60 ℃; for 5h;

Reference yield:

: 1245940-77-5
(2R)-2-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propanoic acid

: 1268634-82-7
N-{(1R)-1-(5-Amino-1,3,4-oxadiazol-2-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0.33 h / 20 °C

1.2: 0 °C

2.1: methanol / 5 h / 60 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; acetonitrile;

Reference yield:

: 536-40-3
4-chlorobenzoic acid hydrazide

: 1268634-82-7
N-{(1R)-1-(5-Amino-1,3,4-oxadiazol-2-yl)-1-[3-(trifluoromethyl)phenyl]ethyl}-2-{3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: tetrahydrofuran / 2 h / 50 °C

2.1: sodium hydroxide; water / Reflux

2.2: pH 1

3.1: pyridine / 35 °C / Inert atmosphere

3.2: 70 °C

4.1: sodium tetrahydroborate; methanol / water; methanol / Cooling with ice

5.1: potassium carbonate; potassium iodide / acetonitrile / 1 h / Reflux

6.1: chiral selector poly(N-methacryloyl-L-isoleucine-3-pentylamide)-based silica gel column / ethyl acetate; 2-Methylpentane / 24 °C / Resolution of racemate

7.1: water; lithium hydroxide / methanol / 1 h / 20 °C

7.2: pH 1 - 2

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.33 h / 20 °C

8.2: 1 h / 20 °C

9.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 0.33 h / 20 °C

9.2: 0 °C

10.1: methanol / 5 h / 60 °C

With pyridine; methanol; sodium tetrahydroborate; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; 2-Methylpentane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;