Technology Process of 2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-(diethoxymethyl)-3-fluoro-N-tritylpyridin-4-amine
There total 3 articles about 2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-(diethoxymethyl)-3-fluoro-N-tritylpyridin-4-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium iodide; potassium phosphate; copper(l) iodide / acetonitrile / 24 h / 60 - 70 °C / Inert atmosphere
2: caesium carbonate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere
With
potassium phosphate; copper(l) iodide; caesium carbonate; potassium iodide;
In
dimethyl sulfoxide; acetonitrile;
1: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.oprd.9b00302
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyridine / ethanol; water / 17 h / 20 °C / Inert atmosphere
2: zinc; acetic acid / 1 h / 100 °C
3: caesium carbonate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere
With
pyridine; caesium carbonate; acetic acid; zinc;
In
ethanol; water; dimethyl sulfoxide;
DOI:10.1021/acs.oprd.9b00302
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrachloromethane / 5 - 10 °C
1.2: 5 - 65 °C
1.3: 2 h / 76 °C
2.1: potassium iodide; potassium phosphate; copper(l) iodide / acetonitrile / 24 h / 60 - 70 °C / Inert atmosphere
3.1: caesium carbonate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere
With
potassium phosphate; copper(l) iodide; caesium carbonate; potassium iodide;
In
tetrachloromethane; dimethyl sulfoxide; acetonitrile;
2.1: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.oprd.9b00302
