(2R,6S)-(-)-2-[(1S,2R,4R,S_R)-(2-hydroxy-7,7-dimethylbicyclo[2.2.1]hept-1-yl)methylsulfinyl]-4-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

Base Information

• Chemical Name: (2R,6S)-(-)-2-[(1S,2R,4R,S_R)-(2-hydroxy-7,7-dimethylbicyclo[2.2.1]hept-1-yl)methylsulfinyl]-4-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione
• CAS No.: 712018-62-7
• Molecular Formula: C₂₉H₃₆INO₆S
• Molecular Weight: 653.578

Synonyms:(2R,6S)-(-)-2-[(1S,2R,4R,S_R)-(2-hydroxy-7,7-dimethylbicyclo[2.2.1]hept-1-yl)methylsulfinyl]-4-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

Chemical Property of (2R,6S)-(-)-2-[(1S,2R,4R,S_R)-(2-hydroxy-7,7-dimethylbicyclo[2.2.1]hept-1-yl)methylsulfinyl]-4-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of (2R,6S)-(-)-2-[(1S,2R,4R,S_R)-(2-hydroxy-7,7-dimethylbicyclo[2.2.1]hept-1-yl)methylsulfinyl]-4-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

There total 4 articles about (2R,6S)-(-)-2-[(1S,2R,4R,S_R)-(2-hydroxy-7,7-dimethylbicyclo[2.2.1]hept-1-yl)methylsulfinyl]-4-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(2R,6S)-4-[2-(3,4-dimethoxyphenyl)ethyl]-2-[(1S,2R,4R,SR)-(2-hydroxy-7,7-dimethylbicyclo[2.2.1]hept-1-yl)methylsulfinyl]-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (446063-56-5) → (2R,6S)-(-)-2-[(1S,2R,4R,SR)-(2-hydroxy-7,7-dimethylbicyclo[2.2.1]hept-1-yl)methylsulfinyl]-4-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (712018-62-7)

Guidance literature:

With iodine; silver trifluoroacetate; In chloroform; at 20 ℃; for 14h;

DOI:10.1021/jo049672o

Reference yield:

1‐(3,4‐dimethoxyphenethyl)‐1H‐pyrrole‐2,5‐dione (37597-19-6) → (2R,6S)-(-)-2-[(1S,2R,4R,SR)-(2-hydroxy-7,7-dimethylbicyclo[2.2.1]hept-1-yl)methylsulfinyl]-4-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (712018-62-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 86 percent / Et₃N / CH₂Cl₂ / 24 h / 20 °C

2: 84 percent / NCS / CCl₄ / 16 h / Heating

3: 97 percent / MCPBA / CH₂Cl₂ / 0 - 20 °C

4: CH₂Cl₂ / 0 °C

5: 87 percent / CF₃CO₂Ag; I₂ / CHCl₃ / 14 h / 20 °C

With N-chloro-succinimide; iodine; silver trifluoroacetate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrachloromethane; dichloromethane; chloroform; 4: Diels-Alder reaction;

DOI:10.1021/jo049672o

Reference yield:

(-)-[(1S,2R,4R)-(2-hydroxy-7,7-dimethylbicyclo[2.2.1]-1-yl)methylsulfanyl]-N-[2-(3,4-dimethoxyphenyl)ethyl]maleimide (446063-58-7) → (2R,6S)-(-)-2-[(1S,2R,4R,SR)-(2-hydroxy-7,7-dimethylbicyclo[2.2.1]hept-1-yl)methylsulfinyl]-4-[2-(2-iodo-4,5-dimethoxyphenyl)ethyl]-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (712018-62-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / MCPBA / CH₂Cl₂ / 0 - 20 °C

2: CH₂Cl₂ / 0 °C

3: 87 percent / CF₃CO₂Ag; I₂ / CHCl₃ / 14 h / 20 °C

With iodine; silver trifluoroacetate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform; 2: Diels-Alder reaction;

DOI:10.1021/jo049672o

upstream raw materials:

(2R,6S)-4-[2-(3,4-dimethoxyphenyl)ethyl]-2-[(1S,2R,4R,S_R)-(2-hydroxy-7,7-dimethylbicyclo[2.2.1]hept-1-yl)methylsulfinyl]-4-aza-tricyclo[5.2.1.0^2,6]dec-8-ene-3,5-dione

1‐(3,4‐dimethoxyphenethyl)‐1H‐pyrrole‐2,5‐dione

(-)-[(1S,2R,4R)-(2-hydroxy-7,7-dimethylbicyclo[2.2.1]-1-yl)methylsulfanyl]-N-[2-(3,4-dimethoxyphenyl)ethyl]succinimide

(-)-[(1S,2R,4R)-(2-hydroxy-7,7-dimethylbicyclo[2.2.1]-1-yl)methylsulfanyl]-N-[2-(3,4-dimethoxyphenyl)ethyl]maleimide

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