[(R)-1-((R)-2-Amino-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid (1R,2R)-2-methyl-cyclohexyl ester

Base Information

Chemical Name:[(R)-1-((R)-2-Amino-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid (1R,2R)-2-methyl-cyclohexyl ester
CAS No.:146516-48-5
Molecular Formula:C₂₈H₃₆N₄O₃
Molecular Weight:476.619
Hs Code.:

Synonyms:[(R)-1-((R)-2-Amino-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid (1R,2R)-2-methyl-cyclohexyl ester

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Chemical Property of [(R)-1-((R)-2-Amino-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid (1R,2R)-2-methyl-cyclohexyl ester

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Technology Process of [(R)-1-((R)-2-Amino-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid (1R,2R)-2-methyl-cyclohexyl ester

There total 5 articles about [(R)-1-((R)-2-Amino-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid (1R,2R)-2-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: [(R)-1-((R)-2-Benzyloxycarbonylamino-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid (1R,2R)-2-methyl-cyclohexyl ester

: 146516-48-5
[(R)-1-((R)-2-Amino-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid (1R,2R)-2-methyl-cyclohexyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 30 ℃; for 2h; under 2585.7 Torr;
DOI:10.1021/jm00057a005

Reference yield:

: 19043-03-9
(1R,2R)-(-)-trans-2-methylcyclohexanol

: 146516-48-5
[(R)-1-((R)-2-Amino-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid (1R,2R)-2-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) pyridine, 2.) Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) THF, RT, 3 h

2: 97 percent / aq. LiOH / dioxane / 36 h / Ambient temperature

3: 1.) pentafluorophenol, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 4 h, 2.) EtOAc, RT, 16 h

4: 80 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 30 °C / 2585.7 Torr

With pyridine; lithium hydroxide; 2,3,4,5,6-pentafluorophenol; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol;
DOI:10.1021/jm00057a005

Reference yield:

: 96551-27-8
α-methyl-(R)-tryptophan methyl ester

: 146516-48-5
[(R)-1-((R)-2-Amino-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid (1R,2R)-2-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) pyridine, 2.) Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) THF, RT, 3 h

2: 97 percent / aq. LiOH / dioxane / 36 h / Ambient temperature

3: 1.) pentafluorophenol, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 4 h, 2.) EtOAc, RT, 16 h

4: 80 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 30 °C / 2585.7 Torr

With pyridine; lithium hydroxide; 2,3,4,5,6-pentafluorophenol; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol;
DOI:10.1021/jm00057a005