butanoic acid, (1R-{1α[RS(RS)],2β})-4-[(2-{[3-(1H-indol-3-yl)-2-methyl-2-({[(2-methylcyclohexyl)oxy]carbonyl}amino)-1-oxopropyl]amino}-1-phenylethyl)amino]-4-oxo-

Base Information

Chemical Name:butanoic acid, (1R-{1α[RS(RS)],2β})-4-[(2-{[3-(1H-indol-3-yl)-2-methyl-2-({[(2-methylcyclohexyl)oxy]carbonyl}amino)-1-oxopropyl]amino}-1-phenylethyl)amino]-4-oxo-
CAS No.:134557-62-3
Molecular Formula:C₃₂H₄₀N₄O₆
Molecular Weight:576.693
Hs Code.:

Synonyms:butanoic acid, (1R-{1α[RS(RS)],2β})-4-[(2-{[3-(1H-indol-3-yl)-2-methyl-2-({[(2-methylcyclohexyl)oxy]carbonyl}amino)-1-oxopropyl]amino}-1-phenylethyl)amino]-4-oxo-

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Chemical Property of butanoic acid, (1R-{1α[RS(RS)],2β})-4-[(2-{[3-(1H-indol-3-yl)-2-methyl-2-({[(2-methylcyclohexyl)oxy]carbonyl}amino)-1-oxopropyl]amino}-1-phenylethyl)amino]-4-oxo-

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Technology Process of butanoic acid, (1R-{1α[RS(RS)],2β})-4-[(2-{[3-(1H-indol-3-yl)-2-methyl-2-({[(2-methylcyclohexyl)oxy]carbonyl}amino)-1-oxopropyl]amino}-1-phenylethyl)amino]-4-oxo-

There total 6 articles about butanoic acid, (1R-{1α[RS(RS)],2β})-4-[(2-{[3-(1H-indol-3-yl)-2-methyl-2-({[(2-methylcyclohexyl)oxy]carbonyl}amino)-1-oxopropyl]amino}-1-phenylethyl)amino]-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 108-30-5
succinic acid anhydride

: 146516-48-5
[(R)-1-((R)-2-Amino-2-phenyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid (1R,2R)-2-methyl-cyclohexyl ester

: 134557-62-3
butanoic acid, (1R-{1α[RS(RS)],2β})-4-[(2-{[3-(1H-indol-3-yl)-2-methyl-2-({[(2-methylcyclohexyl)oxy]carbonyl}amino)-1-oxopropyl]amino}-1-phenylethyl)amino]-4-oxo-

Guidance literature:: In ethyl acetate; for 16h; Ambient temperature;
DOI:10.1021/jm00057a005

Reference yield:

: 19043-03-9
(1R,2R)-(-)-trans-2-methylcyclohexanol

: 134557-62-3
butanoic acid, (1R-{1α[RS(RS)],2β})-4-[(2-{[3-(1H-indol-3-yl)-2-methyl-2-({[(2-methylcyclohexyl)oxy]carbonyl}amino)-1-oxopropyl]amino}-1-phenylethyl)amino]-4-oxo-

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) pyridine, 2.) Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) THF, RT, 3 h

2: 97 percent / aq. LiOH / dioxane / 36 h / Ambient temperature

3: 1.) pentafluorophenol, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 4 h, 2.) EtOAc, RT, 16 h

4: 80 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 30 °C / 2585.7 Torr

5: 77 percent / ethyl acetate / 16 h / Ambient temperature

With pyridine; lithium hydroxide; 2,3,4,5,6-pentafluorophenol; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol; ethyl acetate;
DOI:10.1021/jm00057a005

Reference yield:

: 96551-27-8
α-methyl-(R)-tryptophan methyl ester

: 134557-62-3
butanoic acid, (1R-{1α[RS(RS)],2β})-4-[(2-{[3-(1H-indol-3-yl)-2-methyl-2-({[(2-methylcyclohexyl)oxy]carbonyl}amino)-1-oxopropyl]amino}-1-phenylethyl)amino]-4-oxo-

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) pyridine, 2.) Et₃N / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) THF, RT, 3 h

2: 97 percent / aq. LiOH / dioxane / 36 h / Ambient temperature

3: 1.) pentafluorophenol, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, 0 deg C, 4 h, 2.) EtOAc, RT, 16 h

4: 80 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 30 °C / 2585.7 Torr

5: 77 percent / ethyl acetate / 16 h / Ambient temperature

With pyridine; lithium hydroxide; 2,3,4,5,6-pentafluorophenol; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; ethanol; ethyl acetate;
DOI:10.1021/jm00057a005