2-(tert-butyl-dimethyl-silanyloxy)-6-[6-(tert-butyl-dimethyl-silanyloxy)-hex-2-enyl]-benzoic acid cyanomethyl ester

Base Information

Chemical Name:2-(tert-butyl-dimethyl-silanyloxy)-6-[6-(tert-butyl-dimethyl-silanyloxy)-hex-2-enyl]-benzoic acid cyanomethyl ester
CAS No.:462629-25-0
Molecular Formula:C₂₇H₄₅NO₄Si₂
Molecular Weight:503.83
Hs Code.:

2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-6-[6-(<i>tert</i>-butyl-dimethyl-silanyloxy)-hex-2-enyl]-benzoic acid cyanomethyl ester

Synonyms:2-(tert-butyl-dimethyl-silanyloxy)-6-[6-(tert-butyl-dimethyl-silanyloxy)-hex-2-enyl]-benzoic acid cyanomethyl ester

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Chemical Property of 2-(tert-butyl-dimethyl-silanyloxy)-6-[6-(tert-butyl-dimethyl-silanyloxy)-hex-2-enyl]-benzoic acid cyanomethyl ester

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Technology Process of 2-(tert-butyl-dimethyl-silanyloxy)-6-[6-(tert-butyl-dimethyl-silanyloxy)-hex-2-enyl]-benzoic acid cyanomethyl ester

There total 7 articles about 2-(tert-butyl-dimethyl-silanyloxy)-6-[6-(tert-butyl-dimethyl-silanyloxy)-hex-2-enyl]-benzoic acid cyanomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 438186-97-1
2-bromomethyl-6-(tert-butyl-dimethyl-silanyloxy)-benzoic acid cyanomethyl ester

: 127020-48-8,127020-47-7
(Z)-tert-butyldimethyl((5-(tributylstannyl)pent-4-en-1-yl)oxy)silane

: 462629-25-0
2-(tert-butyl-dimethyl-silanyloxy)-6-[6-(tert-butyl-dimethyl-silanyloxy)-hex-2-enyl]-benzoic acid cyanomethyl ester

Guidance literature:: With triphenyl-arsane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/ja0352350

Reference yield:

: 567-61-3
2-hydroxy-6-methylbenzoic acid

: 462629-25-0
2-(tert-butyl-dimethyl-silanyloxy)-6-[6-(tert-butyl-dimethyl-silanyloxy)-hex-2-enyl]-benzoic acid cyanomethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / Et₃N / acetone / 3 h / Heating

2: 99 percent / imidazole / dimethylformamide / 20 °C

3: 72 percent / N-bromosuccinimide; AIBN / CCl₄ / 3 h / Heating

4: 60 percent / AsPh₃ / Pd₂(dba)3-CHCl₃ / tetrahydrofuran / 2 h / Heating

With 1H-imidazole; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); triphenyl-arsane; triethylamine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; acetone; 4: Stille coupling;
DOI:10.1021/ja0352350

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 462629-25-0
2-(tert-butyl-dimethyl-silanyloxy)-6-[6-(tert-butyl-dimethyl-silanyloxy)-hex-2-enyl]-benzoic acid cyanomethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / imidazole / dimethylformamide / 20 °C

2: 72 percent / N-bromosuccinimide; AIBN / CCl₄ / 3 h / Heating

3: 60 percent / AsPh₃ / Pd₂(dba)3-CHCl₃ / tetrahydrofuran / 2 h / Heating

With 1H-imidazole; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); triphenyl-arsane; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide; 3: Stille coupling;
DOI:10.1021/ja0352350