2-[(4-cyanophenyl)-(3H-imidazol-4-yl)methoxy]ethyl methane-sulphonate

Base Information

Chemical Name:2-[(4-cyanophenyl)-(3H-imidazol-4-yl)methoxy]ethyl methane-sulphonate
CAS No.:1056933-91-5
Molecular Formula:C₁₄H₁₅N₃O₄S
Molecular Weight:321.357
Hs Code.:

Synonyms:2-[(4-cyanophenyl)-(3H-imidazol-4-yl)methoxy]ethyl methane-sulphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[(4-cyanophenyl)-(3H-imidazol-4-yl)methoxy]ethyl methane-sulphonate

Chemical Property:

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Technology Process of 2-[(4-cyanophenyl)-(3H-imidazol-4-yl)methoxy]ethyl methane-sulphonate

There total 4 articles about 2-[(4-cyanophenyl)-(3H-imidazol-4-yl)methoxy]ethyl methane-sulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 952678-31-8
4-[(2-hydroxyethoxy)-(3H-imidazol-4-yl)methyl]benzonitrile

: 124-63-0
methanesulfonyl chloride

: 1056933-91-5
2-[(4-cyanophenyl)-(3H-imidazol-4-yl)methoxy]ethyl methane-sulphonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 3h;

Reference yield:

: 952678-32-9
ethyl [(4-cyano-phenyl)-1-(1-trityl-1H-imidazol-4-yl)methoxy]acetate

: 1056933-91-5
2-[(4-cyanophenyl)-(3H-imidazol-4-yl)methoxy]ethyl methane-sulphonate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

Reference yield:

: 3058-39-7
4-iodobenzonitrile

: 1056933-91-5
2-[(4-cyanophenyl)-(3H-imidazol-4-yl)methoxy]ethyl methane-sulphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1 h / -30 °C

1.2: 0.5 h / -30 °C

1.3: 20 °C

2.1: sodium hydride / paraffin oil (nujol); N,N-dimethyl-formamide / 1 h / 0 °C

2.2: 16 h / 20 °C

3.1: sodium tetrahydroborate / ethanol / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C

With sodium tetrahydroborate; isopropylmagnesium chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; paraffin oil (nujol); ethanol; dichloromethane; N,N-dimethyl-formamide;