(S)-tert-butyl 1-oxo-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 1-oxo-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate
CAS No.:1041024-61-6
Molecular Formula:C₂₃H₂₄F₃NO₅S
Molecular Weight:483.508
Hs Code.:

Synonyms:(S)-tert-butyl 1-oxo-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate

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Chemical Property of (S)-tert-butyl 1-oxo-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate

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Technology Process of (S)-tert-butyl 1-oxo-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate

There total 8 articles about (S)-tert-butyl 1-oxo-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1039756-00-7
N-{[2-(trifluoromethyl)benzene]sulfonyl}aziridine

: 375349-06-7
tert-butyl 2,3-dihydro-1-oxo-1H-indene-2-carboxylate

: 1041024-61-6
(S)-tert-butyl 1-oxo-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: With dipotassium hydrogenphosphate; O-1-adamantoyl-N-9-anthracenylmethyl cinchonium chloride; In chloroform; toluene; at -20 ℃; for 72h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ja8036965

Reference yield: 80.0%

: 1215021-55-8
3-{[2-(trifluoromethyl)phenyl]sulfonyl}1,2,3-oxathiazolidine 2,2-dioxide

: 375349-06-7
tert-butyl 2,3-dihydro-1-oxo-1H-indene-2-carboxylate

: 1041024-61-6
(S)-tert-butyl 1-oxo-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: 3-{[2-(trifluoromethyl)phenyl]sulfonyl}1,2,3-oxathiazolidine 2,2-dioxide; tert-butyl 2,3-dihydro-1-oxo-1H-indene-2-carboxylate; With C₄₅H₄₇N₂O₂⁽¹⁺⁾*Cl^(1-); caesium carbonate; In 5,5-dimethyl-1,3-cyclohexadiene; at 0 ℃; for 72h;

With hydrogenchloride; water; In 5,5-dimethyl-1,3-cyclohexadiene; at 0 - 20 ℃; for 0.166667h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/anie.200905329

Reference yield:

: 1039756-00-7
N-{[2-(trifluoromethyl)benzene]sulfonyl}aziridine

: 375349-06-7
tert-butyl 2,3-dihydro-1-oxo-1H-indene-2-carboxylate

: C₂₃H₂₄F₃NO₅S

: 1041024-61-6
(S)-tert-butyl 1-oxo-2-(2-(2-(trifluoromethyl)phenylsulfonamido)ethyl)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: With C₃₇H₃₇N₂O⁽¹⁺⁾*Cl^(1-); caesium carbonate; In chloroform; toluene; at 0 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ja8036965