tert-butyl 4-<<6--3-<2-(N,N-dimethylcarbamoyl)propyl>indol-1-yl>methyl>-3-methoxybenzoate

Base Information

Chemical Name:tert-butyl 4-<<6--3-<2-(N,N-dimethylcarbamoyl)propyl>indol-1-yl>methyl>-3-methoxybenzoate
CAS No.:114086-27-0
Molecular Formula:C₃₄H₄₅N₃O₅
Molecular Weight:575.748
Hs Code.:

tert-butyl 4-<<6-<N-(cyclopentylmethyl)carbamoyl>-3-<2-(N,N-dimethylcarbamoyl)propyl>indol-1-yl>methyl>-3-methoxybenzoate

Synonyms:tert-butyl 4-<<6--3-<2-(N,N-dimethylcarbamoyl)propyl>indol-1-yl>methyl>-3-methoxybenzoate

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Chemical Property of tert-butyl 4-<<6--3-<2-(N,N-dimethylcarbamoyl)propyl>indol-1-yl>methyl>-3-methoxybenzoate

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Technology Process of tert-butyl 4-<<6--3-<2-(N,N-dimethylcarbamoyl)propyl>indol-1-yl>methyl>-3-methoxybenzoate

There total 6 articles about tert-butyl 4-<<6--3-<2-(N,N-dimethylcarbamoyl)propyl>indol-1-yl>methyl>-3-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 114086-27-0
tert-butyl 4-<<6--3-<2-(N,N-dimethylcarbamoyl)propyl>indol-1-yl>methyl>-3-methoxybenzoate

Guidance literature:

Reference yield:

: 114085-90-4
6--3-formylindole

: 114086-27-0
tert-butyl 4-<<6--3-<2-(N,N-dimethylcarbamoyl)propyl>indol-1-yl>methyl>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / K₂CO₃ / dimethylformamide / 48 h

2: 99 percent / dioxane / 18 h / Heating

3: 99 percent / H₂ / 10percent Pd/C / methanol / 18 h / 2585.7 Torr

4: 95 percent / aq. LiOH / tetrahydrofuran; methanol / 6 h / 30 °C

5: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, reflux, 1 h, 2.) CH₂Cl₂, 60 deg C, 90 h

With lithium hydroxide; hydrogen; potassium carbonate; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00091a010

Reference yield:

: 114085-91-5
tert-butyl 4-<<6--3-formylindol-1-yl>methyl>-3-methoxybenzoate

: 114086-27-0
tert-butyl 4-<<6--3-<2-(N,N-dimethylcarbamoyl)propyl>indol-1-yl>methyl>-3-methoxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / dioxane / 18 h / Heating

2: 99 percent / H₂ / 10percent Pd/C / methanol / 18 h / 2585.7 Torr

3: 95 percent / aq. LiOH / tetrahydrofuran; methanol / 6 h / 30 °C

4: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, reflux, 1 h, 2.) CH₂Cl₂, 60 deg C, 90 h

With lithium hydroxide; hydrogen; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1021/jm00091a010