N-[N-(4-morpholinecarbonyl)-L-(4-methyl)leucinyl]-L-(O-benzyl)serinamide

Base Information

Chemical Name:N-[N-(4-morpholinecarbonyl)-L-(4-methyl)leucinyl]-L-(O-benzyl)serinamide
CAS No.:479091-77-5
Molecular Formula:C₂₂H₃₄N₄O₅
Molecular Weight:434.536
Hs Code.:

Synonyms:N-[N-(4-morpholinecarbonyl)-L-(4-methyl)leucinyl]-L-(O-benzyl)serinamide

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Chemical Property of N-[N-(4-morpholinecarbonyl)-L-(4-methyl)leucinyl]-L-(O-benzyl)serinamide

Chemical Property:

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Technology Process of N-[N-(4-morpholinecarbonyl)-L-(4-methyl)leucinyl]-L-(O-benzyl)serinamide

There total 5 articles about N-[N-(4-morpholinecarbonyl)-L-(4-methyl)leucinyl]-L-(O-benzyl)serinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23680-31-1
BOC-O-benzyl-L-serine

: 479091-77-5
N-[N-(4-morpholinecarbonyl)-L-(4-methyl)leucinyl]-L-(O-benzyl)serinamide

Guidance literature:: Multi-step reaction with 5 steps

1: 11.5 g / NH₄OH; EDC; HOBt / dimethylformamide / 16 h / 20 °C

2: TFA / CH₂Cl₂ / 0.5 h / 20 °C

3: Hunig's base; EDC; HOBt / CH₂Cl₂ / 16 h / 20 °C

4: 94 percent / cyclohexene / 10percent Pd/C / ethanol / 1 h / 75 °C

5: 150 mg / DIPEA; DMAP / CH₂Cl₂ / 16 h / 20 °C

With dmap; ammonium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; cyclohexene; 10percent Pd/C; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020209i

Reference yield:

: 67320-80-3
(S)-2-Amino-3-benzyloxy-propionamide

: 479091-77-5
N-[N-(4-morpholinecarbonyl)-L-(4-methyl)leucinyl]-L-(O-benzyl)serinamide

Guidance literature:: Multi-step reaction with 3 steps

1: Hunig's base; EDC; HOBt / CH₂Cl₂ / 16 h / 20 °C

2: 94 percent / cyclohexene / 10percent Pd/C / ethanol / 1 h / 75 °C

3: 150 mg / DIPEA; DMAP / CH₂Cl₂ / 16 h / 20 °C

With dmap; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; cyclohexene; 10percent Pd/C; In ethanol; dichloromethane;
DOI:10.1021/jm020209i

Reference yield:

: 78331-03-0
N-(t-butoxycarbonyl)-L-(O-benzyl)serinamide

: 479091-77-5
N-[N-(4-morpholinecarbonyl)-L-(4-methyl)leucinyl]-L-(O-benzyl)serinamide

Guidance literature:: Multi-step reaction with 4 steps

1: TFA / CH₂Cl₂ / 0.5 h / 20 °C

2: Hunig's base; EDC; HOBt / CH₂Cl₂ / 16 h / 20 °C

3: 94 percent / cyclohexene / 10percent Pd/C / ethanol / 1 h / 75 °C

4: 150 mg / DIPEA; DMAP / CH₂Cl₂ / 16 h / 20 °C

With dmap; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; cyclohexene; 10percent Pd/C; In ethanol; dichloromethane;
DOI:10.1021/jm020209i