tert-butyl-3-(2-(methoxycarbonyl)-6-iodophenoxy)-propyl carbamate

Base Information

Chemical Name:tert-butyl-3-(2-(methoxycarbonyl)-6-iodophenoxy)-propyl carbamate
CAS No.:1385774-57-1
Molecular Formula:C₁₆H₂₂INO₅
Molecular Weight:435.259
Hs Code.:

Synonyms:tert-butyl-3-(2-(methoxycarbonyl)-6-iodophenoxy)-propyl carbamate

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Chemical Property of tert-butyl-3-(2-(methoxycarbonyl)-6-iodophenoxy)-propyl carbamate

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Technology Process of tert-butyl-3-(2-(methoxycarbonyl)-6-iodophenoxy)-propyl carbamate

There total 2 articles about tert-butyl-3-(2-(methoxycarbonyl)-6-iodophenoxy)-propyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 128033-28-3
methyl 2-hydroxy-3-iodobenzoate

: 83948-53-2
3-bromopropylamine tert-butylcarbamate

: 1385774-57-1
tert-butyl-3-(2-(methoxycarbonyl)-6-iodophenoxy)-propyl carbamate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c2ob25618e

Reference yield:

: 533-58-4
2-Iodophenol

: 1385774-57-1
tert-butyl-3-(2-(methoxycarbonyl)-6-iodophenoxy)-propyl carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; magnesium chloride / tetrahydrofuran / 12 h / Inert atmosphere; Reflux

2: sodium cyanide; manganese(IV) oxide; acetic acid / 12 h / 20 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere

With sodium cyanide; manganese(IV) oxide; caesium carbonate; acetic acid; triethylamine; magnesium chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25618e

Reference yield:

: 1385774-57-1
tert-butyl-3-(2-(methoxycarbonyl)-6-iodophenoxy)-propyl carbamate

: 1385774-62-8
10-(2-(2,4-difluorophenyl) ethynyl)-2,3,4,5-tetrahydrobenzo [b][1,5]oxazocin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 4 h / Inert atmosphere

2: water; lithium hydroxide / methanol

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 48 h / 0 - 20 °C / Inert atmosphere

4: piperidine; copper(l) iodide; palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 12 h / 60 °C / Inert atmosphere

With piperidine; copper(l) iodide; water; palladium diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; lithium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide; 4: Sonogashira cross-coupling;
DOI:10.1039/c2ob25618e