6-chloro-2-(trifluoromethyl)nicotinonitrile

Base Information

• Chemical Name: 6-chloro-2-(trifluoromethyl)nicotinonitrile
• CAS No.: 1245913-20-5
• Molecular Formula: C₇H₂ClF₃N₂
• Molecular Weight: 206.554
• Hs Code.: 2933399990
• Mol file: 1245913-20-5.mol

Synonyms:6-chloro-2-(trifluoromethyl)nicotinonitrile

Chemical Property of 6-chloro-2-(trifluoromethyl)nicotinonitrile

Chemical Property:

• Boiling Point: 225.7±35.0 °C(Predicted)
• PKA: -8.00±0.10(Predicted)
• Density: 1.51±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

6-Chloro-2-(trifluoromethyl)nicotinonitrile 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-2-(trifluoromethyl)nicotinonitrile

There total 1 articles about 6-chloro-2-(trifluoromethyl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

6-chloronicotinonitrile (33252-28-7) + bis(((trifluoromethyl)sulfinyl)oxy)zinc (39971-65-8) → 6-chloro-2-(trifluoromethyl)nicotinonitrile (1245913-20-5)

Guidance literature:

With tert.-butylhydroperoxide; bis-(((isopropyl)sulfinyl)oxy)zinc; zinc sulfinate; In water; dimethyl sulfoxide; at 20 - 50 ℃; for 12h; regioselective reaction;

DOI:10.1021/ja406223k

Reference yield:

6-chloro-2-(trifluoromethyl)nicotinonitrile (1245913-20-5) + 3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)azetidin-3-ol hydrochloride → 6-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxyazetidin-1-yl)-2-(trifluoromethyl)nicotinonitrile

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h; Sealed tube;

upstream raw materials:

6-chloronicotinonitrile

bis(((trifluoromethyl)sulfinyl)oxy)zinc

Refernces