2-Amino-3-benzoylpyridine

Base Information

• Chemical Name: 2-Amino-3-benzoylpyridine
• CAS No.: 3810-10-4
• Molecular Formula: C12H10N2O
• Molecular Weight: 198.224
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90507654
• Nikkaji Number: J2.227.154G
• Wikidata: Q82364007
• Mol file: 3810-10-4.mol

Synonyms:2-Amino-3-benzoylpyridine;3810-10-4;(2-Aminopyridin-3-yl)(phenyl)methanone;(2-amino-pyridin-3-yl)-phenyl-methanone;(2-aminopyridin-3-yl)-phenylmethanone;Methanone, (2-amino-3-pyridinyl)phenyl-;SCHEMBL4851229;DTXSID90507654;KROYVOKHXIFHMV-UHFFFAOYSA-N;AKOS007930182;(2-TERT-BUTYLPHENOXY)ACETICACID;SB36944;(2-amino-3-pyridinyl)(phenyl)methanone;AC-10009;BS-51641;CS-0342047;FT-0650482;E77021

Chemical Property of 2-Amino-3-benzoylpyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 145-148 °C
• Refractive Index: 1.635
• Boiling Point: 403.246 °C at 760 mmHg
• PKA: 4.79±0.36(Predicted)
• Flash Point: 197.676 °C
• PSA: 55.98000
• Density: 1.216 g/cm³
• LogP: 2.47600
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Dichloromethane, Methanol
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 198.079312947
• Heavy Atom Count: 15
• Complexity: 224

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-3-benzoylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=C(N=CC=C2)N

Technology Process of 2-Amino-3-benzoylpyridine

There total 26 articles about 2-Amino-3-benzoylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2-fluoropyridin-3-yl)phenylmethanone (79574-71-3) → 2-amino-3-benzoylpyridine (3810-10-4)

Guidance literature:

With ammonia; In water; Heating;

DOI:10.1016/S0022-328X(00)80124-2

Reference yield: 90.0%

3-benzoyl-2-chloro-pyridine (80099-81-6) → 2-amino-3-benzoylpyridine (3810-10-4)

Guidance literature:

With ammonium hydroxide; at 100 ℃; for 2h;

Reference yield: 83.0%

2-amino-3-pyridinecarbonitrile (24517-64-4) + sodium benzenesulfonate (873-55-2) → 2-amino-3-benzoylpyridine (3810-10-4)

Guidance literature:

With p-nitrobenzenesulfonic acid; palladium diacetate; In tetrahydrofuran; water; at 80 ℃; for 48h; Inert atmosphere; Schlenk technique;

DOI:10.3390/molecules19056439

upstream raw materials:

malonaldehydebis(dimethylacetal)

2-Benzoylacetamidine

2-Benzoylacetimidsaeure-ethylester

3-benzoylpyridine-2-carboxylic acid

Downstream raw materials:

(2-hydroxy-[3]pyridyl)-phenyl ketone

5-phenyl-6,7,8,9-tetrahydrobenzo<1,8>naphthiridine

4-phenyl-1,2-dihydropyrido<2,3-d>-2-pyrimidinone

2-amino-4-phenyl-1,8-naphthyridine-3-carbonitrile