4-((2-ethylisoindolin-5-yl)carbamoyl)-2-(phenylamino)benzoic acid trifluoroacetic acid

Base Information

Chemical Name:4-((2-ethylisoindolin-5-yl)carbamoyl)-2-(phenylamino)benzoic acid trifluoroacetic acid
CAS No.:1456885-59-8
Molecular Formula:C₂HF₃O₂*C₂₄H₂₃N₃O₃
Molecular Weight:515.489
Hs Code.:

Synonyms:4-((2-ethylisoindolin-5-yl)carbamoyl)-2-(phenylamino)benzoic acid trifluoroacetic acid

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Chemical Property of 4-((2-ethylisoindolin-5-yl)carbamoyl)-2-(phenylamino)benzoic acid trifluoroacetic acid

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Technology Process of 4-((2-ethylisoindolin-5-yl)carbamoyl)-2-(phenylamino)benzoic acid trifluoroacetic acid

There total 7 articles about 4-((2-ethylisoindolin-5-yl)carbamoyl)-2-(phenylamino)benzoic acid trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1456885-57-6
4-((2-ethylisoindolin-5-yl)carbamoyl)-2-(phenylamino)benzoic acid trifluoroacetic acid

: 75-07-0,9002-91-9
acetaldehyde

: 1456885-59-8
4-((2-ethylisoindolin-5-yl)carbamoyl)-2-(phenylamino)benzoic acid trifluoroacetic acid

Guidance literature:: 4-((2-ethylisoindolin-5-yl)carbamoyl)-2-(phenylamino)benzoic acid trifluoroacetic acid; With palladium 10% on activated carbon; hydrogen; In methanol; for 0.333333h;

acetaldehyde; In methanol; at 20 ℃; for 2h;
DOI:10.1021/jm400919p

Reference yield:

: 586-35-6
2-bromo-1,4-benzenedicarboxylic acid

: 1456885-59-8
4-((2-ethylisoindolin-5-yl)carbamoyl)-2-(phenylamino)benzoic acid trifluoroacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; copper(l) iodide; copper / water / Reflux

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane

4.1: palladium 10% on activated carbon; hydrogen / methanol / 0.33 h

4.2: 2 h / 20 °C

With copper(l) iodide; palladium 10% on activated carbon; hydrogen; copper; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400919p

Reference yield:

: 566155-75-7
2-(phenylamino)terephthalic acid

: 1456885-59-8
4-((2-ethylisoindolin-5-yl)carbamoyl)-2-(phenylamino)benzoic acid trifluoroacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane

3.1: palladium 10% on activated carbon; hydrogen / methanol / 0.33 h

3.2: 2 h / 20 °C

With palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm400919p