(E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorobenzyloxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]benzoic acid

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Chemical Name:(E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorobenzyloxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]benzoic acid
CAS No.:1448617-79-5
Molecular Formula:C₃₇H₃₈F₂O₇
Molecular Weight:632.701
Hs Code.:

Synonyms:(E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorobenzyloxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]benzoic acid

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Chemical Property of (E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorobenzyloxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]benzoic acid

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Technology Process of (E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorobenzyloxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]benzoic acid

There total 4 articles about (E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorobenzyloxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1448617-78-4
methyl (E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorophenylmethoxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]-benzoate

: 1448617-79-5
(E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorobenzyloxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]benzoic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 70 ℃; for 20h; Inert atmosphere;
DOI:10.1002/cmdc.201300100

Reference yield:

: 1-[5-(adamant-1-yl)-2-hydroxy-4-(2-methoxyethoxymethoxy)phenyl]ethan-2-one

: 1448617-79-5
(E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorobenzyloxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 16 h / 25 °C / Inert atmosphere

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 - 0 °C / Inert atmosphere

2.2: 19 h / -78 - 25 °C / Inert atmosphere

3.1: sodium hydroxide; water / methanol / 20 h / 70 °C / Inert atmosphere

With n-butyllithium; water; sodium hydride; diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/cmdc.201300100

Reference yield:

: 1448617-76-2
1-[5-(adamant-1-yl)-2-(3,5-difluorophenylmethoxy)-4-(2-methoxyethoxymethoxy)phenyl]ethan-1-one

: 1448617-79-5
(E)-4-[1-(5-adamant-1-yl)-2-(3,5-difluorobenzyloxy)-4-(((2-methoxyethoxy)methoxy)phenyl)-1-oxoprop-2-en-3-yl]benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 - 0 °C / Inert atmosphere

1.2: 19 h / -78 - 25 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 20 h / 70 °C / Inert atmosphere

With n-butyllithium; water; diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; hexane;
DOI:10.1002/cmdc.201300100